OMIA:000515-9544 : Cardiomyopathy, hypertrophic in Macaca mulatta (Rhesus monkey) |
In other species: red kangaroo , brown woolly monkey , dog , domestic cat , pig , Arabian camel , taurine cattle
Categories: Cardiovascular system phene
Single-gene trait/disorder: no
Mode of inheritance: Multifactorial
Disease-related: yes
Key variant known: no
Cross-species summary: Increase in volume of the muscle tissue of the heart, due to an increase in the size of muscle cells, primarily in the left ventricle and ventricular septum.
Markers: Oldt et al. (2020) "uncovered a risk haplotype in the rhesus MYBPC3 gene, which is frequently disrupted in both human and feline HCM; this haplotype implicates an intronic variant strongly associated with disease in either homozygous or carrier form."
Contact us
If you notice anything missing or in need of change, please contact us at: [email protected].
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2020). OMIA:000515-9544: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2025 | van den Dolder, F.W., Dinani, R., Warnaar, V.A.J., Vučković, S., Passadouro, A.S., Nassar, A.A., Ramsaroep, A.X., Burchell, G.B., Schoonmade, L.J., van der Velden, J., Goversen, B. : |
| Experimental models of hypertrophic cardiomyopathy: A systematic review. JACC Basic Transl Sci 10:S2452-302X(24)00396-6:511-546, 2025. Pubmed reference: 40306862. DOI: 10.1016/j.jacbts.2024.10.017. | |
| 2024 | Rivas, V.N., Vandewege, M.W., Ueda, Y., Kaplan, J.L., Reader, J., Roberts, J.A., Stern, J.A. : |
| Transcriptomic and genetic profiling in a spontaneous non-human primate model of hypertrophic cardiomyopathy and sudden cardiac death. Sci Rep 14:31344, 2024. Pubmed reference: 39733099. DOI: 10.1038/s41598-024-82770-4. | |
| 2020 | Oldt, R.F., Bussey, K.J., Settles, M.L., Fass, J.N., Roberts, J.A., Reader, J.R., Komandoor, S., Abrich, V.A., Kanthaswamy, S. : |
| MYBPC3 haplotype linked to hypertrophic cardiomyopathy in rhesus macaques (Macaca mulatta). Comp Med 70:358-67, 2020. Pubmed reference: 32753092. DOI: 10.30802/AALAS-CM-19-000108. |
Edit History
- Created by Frank Nicholas on 08 Aug 2020
- Changed by Frank Nicholas on 08 Aug 2020