OMIA:000515-9544 : Cardiomyopathy, hypertrophic in Macaca mulatta (Rhesus monkey)

In other species: red kangaroo , brown woolly monkey , dog , domestic cat , pig , Arabian camel , taurine cattle

Categories: Cardiovascular system phene

Single-gene trait/disorder: no

Mode of inheritance: Multifactorial

Disease-related: yes

Key variant known: no

Cross-species summary: Increase in volume of the muscle tissue of the heart, due to an increase in the size of muscle cells, primarily in the left ventricle and ventricular septum.

Markers: Oldt et al. (2020) "uncovered a risk haplotype in the rhesus MYBPC3 gene, which is frequently disrupted in both human and feline HCM; this haplotype implicates an intronic variant strongly associated with disease in either homozygous or carrier form."

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Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2020). OMIA:000515-9544: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2025 van den Dolder, F.W., Dinani, R., Warnaar, V.A.J., Vučković, S., Passadouro, A.S., Nassar, A.A., Ramsaroep, A.X., Burchell, G.B., Schoonmade, L.J., van der Velden, J., Goversen, B. :
Experimental models of hypertrophic cardiomyopathy: A systematic review. JACC Basic Transl Sci 10:S2452-302X(24)00396-6:511-546, 2025. Pubmed reference: 40306862. DOI: 10.1016/j.jacbts.2024.10.017.
2024 Rivas, V.N., Vandewege, M.W., Ueda, Y., Kaplan, J.L., Reader, J., Roberts, J.A., Stern, J.A. :
Transcriptomic and genetic profiling in a spontaneous non-human primate model of hypertrophic cardiomyopathy and sudden cardiac death. Sci Rep 14:31344, 2024. Pubmed reference: 39733099. DOI: 10.1038/s41598-024-82770-4.
2020 Oldt, R.F., Bussey, K.J., Settles, M.L., Fass, J.N., Roberts, J.A., Reader, J.R., Komandoor, S., Abrich, V.A., Kanthaswamy, S. :
MYBPC3 haplotype linked to hypertrophic cardiomyopathy in rhesus macaques (Macaca mulatta). Comp Med 70:358-67, 2020. Pubmed reference: 32753092. DOI: 10.30802/AALAS-CM-19-000108.

Edit History


  • Created by Frank Nicholas on 08 Aug 2020
  • Changed by Frank Nicholas on 08 Aug 2020