OMIA 000527 : Hypomyelinogenesis, congenital

Cross-species summary: Congenital deficiency of myelin, especially in the cerebellum and brainstem; includes failure of formation of myelin, plus incomplete and delayed myelination of axons. Clinical signs include inability to rise, and severe muscle tremor with periods of spasticity. Also known as oligodendroglial dysplasia.

Species in which this phene is found:
dog (Canis lupus familiaris)
pig (Sus scrofa)
cattle (Bos taurus)
sheep (Ovis aries)

Edit History


  • Created by Frank Nicholas on 03 May 2005
  • Changed by Frank Nicholas on 17 Sep 2014
  • Changed by Imke Tammen2 on 25 Sep 2021