OMIA:000527-9823 : Hypomyelinogenesis, congenital in Sus scrofa (pig)
Categories: Nervous system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: Congenital deficiency of myelin, especially in the cerebellum and brainstem; includes failure of formation of myelin, plus incomplete and delayed myelination of axons. Clinical signs include inability to rise, and severe muscle tremor with periods of spasticity. Also known as oligodendroglial dysplasia.
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|1970||Patterson, D.S.P., Sweasey, D. :|
|Lipid hexose: phosphorous ratio as an aid to the diagnosis of congenital myelin defects in lambs and piglets Acta Neuropathologia 15:318-326, 1970.|
|1965||Emerson, J.L., Delez, A.L. :|
|Cerebellar hypoplasia, hypomyelinogenesis, and congenital tremors of pigs, associated with prenatal hog cholera vaccination of sows Journal of the American Veterinary Medical Association 147:47-54, 1965. Pubmed reference: 5893210.|
- Created by Frank Nicholas on 06 Sep 2005