OMIA:000527-9615 : Hypomyelinogenesis, congenital in Canis lupus familiaris

In other species: pig , cattle , sheep

Categories: Nervous system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Congenital deficiency of myelin, especially in the cerebellum and brainstem; includes failure of formation of myelin, plus incomplete and delayed myelination of axons. Clinical signs include inability to rise, and severe muscle tremor with periods of spasticity. Also known as oligodendroglial dysplasia.


2006 Morrison, J.P., Schatzberg, S.J., De Lahunta, A., Ross, J.T., Bookbinder, P., Summers, B.A. :
Oligodendroglial dysplasia in two bullmastiff dogs. Vet Pathol 43:29-35, 2006. Pubmed reference: 16407484 . DOI: 10.1354/vp.43-1-29.

Edit History

  • Created by Frank Nicholas on 17 Sep 2014