OMIA:000733-9615 : Multiple ocular defects in Canis lupus familiaris (dog)

In other species: horse , taurine cattle , alpaca

Categories: Vision / eye phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 155550 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific name: see also OMIA:002811-9615 : Multiple ocular defects, COL11A1-related in Canis lupus familiaris (dog)

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Akita (Dog) (VBO_0200010), Cavalier King Charles Spaniel (Dog) (VBO_0200309), Doberman Pinscher (Dog) (VBO_0200442), Old English Sheepdog (Dog) (VBO_0200969), Portuguese Water Dog (Dog) (VBO_0201077), Saint Bernard (Dog) (VBO_0201160).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000733-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2019 Shaw, G.C., Tse, M.P.Y., Miller, A.D. :
Microphthalmia with multiple anterior segment defects in Portuguese Water Dogs. Vet Pathol 56:269-273, 2019. Pubmed reference: 30131012. DOI: 10.1177/0300985818794248.
2015 Bauer, B.S., Sandmeyer, L.S., Grahn, B.H. :
Diagnostic ophthalmology. Microphthalmos and multiple ocular anomalies (MOA) OU consistent with merle ocular dysgenesis (MOD). Can Vet J 56:767-8, 2015. Pubmed reference: 26130844.
1986 Lewis, D.G., Kelly, D.F., Sansom, J. :
Congenital microphthalmia and other developmental ocular anomalies in the Dobermann. Journal of Small Animal Practice 27:559–566, 1986.
1985 Laratta, LJ., Riis, RC., Kern, TJ., Koch, SA. :
Multiple congenital ocular defects in the Akita dog. Cornell Vet 75:381-92, 1985. Pubmed reference: 3926378.
1984 Narfstrom, K., Dubielzig, R. :
Posterior lenticonus, cataracts and microphthalmia; congenital ocular defects in the Cavalier King Charles Spaniel. Journal of Small Animal Practice 25:669–677, 1984.
1979 Barrie, K.P., Peiffer, R., Gelatt, K.N., Williams L.W. :
Posterior lenticonus, microphthalmia, congenital cataracts, and retinal folds in an Old English Sheepdog. Journal of the American Animal Hospital Association 15:1979:715–717, 1979.
1974 Martin, C.L., Leipold, H.W. :
Aphakia and multiple ocular defects in Saint Bernard puppies Veterinary Medicine and Small Animal Clinician 69:448-453, 1974. Pubmed reference: 4206317.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 14 Jan 2024