OMIA:000783-9615 : Pelger-Huet anomaly in Canis lupus familiaris

In other species: domestic cat , rabbit

Categories: Haematopoietic system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 169400 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Mode of inheritance: Autosomal incomplete dominant

Considered a defect: yes

Species-specific symbol: PHA

Inheritance: The inheritance is autosomal semi-dominant with incomplete penetrance (Latimer et al. 2000).

Clinical features: In heterozygous individuals, PHA is a leucocyte development-disorder, in which granulocytes and monocytes show hyposegmentation of the nuclei with a mature, coarse chromatin pattern (Latimer et al. 2000). Those changes are without any clinical relevance, but frequently lead to misdiagnosis as marked left shift, which is normally caused by inflammation, preleucaemic syndrome or drug induced changes in leucocyte morphology. It was speculated that homozygosity for the PHA allele in dogs might have a lethal effect, possibly in utero during development (Latimer et al. 2000).

Breeds: American English Coonhound, Australian Cattle Dog, Australian Shepherd, Border Collie, Boston Terrier, Cocker Spaniel, Danish/swedish Farm Dog (Dog) (VBO_0000663), Foxhound, German Shepherd Dog, Mixed breed (dog), Samoyed.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2011 Lukaszewska, J., Allison, R.W., Stepkowska, J. :
Congenital Pelger-Huët anomaly in a Danish/Swedish Farmdog: case report. Acta Vet Scand 53:14, 2011. Pubmed reference: 21362186 . DOI: 10.1186/1751-0147-53-14.
Vale, A.M., Tomaz, L.R., Sousa, R.S., Soto-Blanco, B. :
Pelger-Huët anomaly in two related mixed-breed dogs. J Vet Diagn Invest 23:863-5, 2011. Pubmed reference: 21908340 . DOI: 10.1177/1040638711407891.
2000 Latimer, K.S., Campagnoli, R.P., Danilenko, D.M. :
Pelger-Huet anomaly in Australian shepherds: 87 cases (1991-1997) Comparative Haematology International 10:9-13, 2000.
1997 Mott, J., Crystal, M.A., Meinkoth, J.H. :
Pelger-Huet anomaly in an Addisonian Canine Practice 22:35-37, 1997.
1989 Latimer, K.S., Kircher, I.M., Lindl, P.A., Dawe, D.L., Brown, J. :
Leukocyte function in Pelger-Huët anomaly of dogs. J Leukoc Biol 45:301-10, 1989. Pubmed reference: 2649629 . DOI: 10.1002/jlb.45.4.301.
1979 Bowles, C.A., Alsaker, R., Wolfle, T.L. :
Studies of the Pelger-Huet anomaly in Foxhounds American Journal of Pathology 96:237-247, 1979. Pubmed reference: 464021 .
1967 Kiss, M., Kómár, G. :
[Pelger-Huet nuclear anomaly in leukocytes in a dog]. Berl Munch Tierarztl Wochenschr 80:474-6, 1967. Pubmed reference: 5628116 .

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Tosso Leeb on 26 May 2020
  • Changed by Tosso Leeb on 30 May 2020
  • Changed by Tosso Leeb on 03 Jun 2020
  • Changed by Imke Tammen2 on 23 Nov 2022