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OMIA:000783-9986 : Pelger-Huet anomaly in Oryctolagus cuniculus (rabbit)

In other species: dog , domestic cat

Categories: Haematopoietic system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 169400 (trait)

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal incomplete dominant

Considered a defect: yes

Key variant known: no

Species-specific symbol: Pg

Species-specific description: See Robinson (1958, pp. 354-355).

History: This disorder was reported first in rabbits (Undritz, 1939, 1943; Klein, 1949; Nachtsheim, 1950) before it was reported in humans (Harm, 1952).

Inheritance: Undritz (1939) and Nachsteim (1950) presented evidence of single-locus inheritance, with heterozygotes showing the disorder and homozygotes showing an extreme form of the disorder, including chondrodysplasia, that results in neonatal death in almost all cases.

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:000783-9986: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2003 Oosterwijk, J.C., Mansour, S., van Noort, G., Waterham, H.R., Hall, C.M., Hennekam, R.C. :
Congenital abnormalities reported in Pelger-Huët homozygosity as compared to Greenberg/HEM dysplasia: highly variable expression of allelic phenotypes. J Med Genet 40:937-41, 2003. Pubmed reference: 14684694. DOI: 10.1136/jmg.40.12.937.
1977 Holtz, C.R., Pfaff, J., Gärtner, K. :
[Studies on the frequency of the Pelger anomaly in the domestic rabbit population]. Zentralbl Veterinarmed A 24:409-12, 1977. Pubmed reference: 407754.
1964 Urasinski, I., Urasniska, A. :
[On the activity of neutrophilic alkaline phosphatase with Pelger-Huet anomaly in rabbits]. Patol Pol 15:233-7, 1964. Pubmed reference: 14241274.
1958 Robinson, R. :
Genetic studies of the rabbit. Bibliographia Genetica 17:229–558, 1958.
1953 Harm, H. :
[Effect of colchicine on the white blood picture of Pelger and non-Pelger rabbits]. Acta Haematol 10:96-105, 1953. Pubmed reference: 13091700.
1952 Harm, H. :
Beitrage zur Morphologic und Gtnetik der Pelger-Anomalie bei Mensch und Kaninchen [Morphology and genetics of the Pelger anomaly in man and the rabbit] Zeitschrift fur menschliche Vererbungs- und Konstitutionslehre 30:501-539, 1952.
1950 Nachtsheim, H. :
The Pelger-anomaly in man and rabbit; a mendelian character of the nuclei of the leucocytes. J Hered 41:131-7, 1950. Pubmed reference: 15436969. DOI: 10.1093/oxfordjournals.jhered.a106108.
1949 Klein, H. :
Die Pelger-Anomalie der Leukocyten und die pathologische Anatomie des neugeborenen homozygoten Pelger-Kaninchens Zeitschrift fur menschliche Vererbungs- und Konstitutionslehre 29:551-620, 1949.
1943 Undritz, E. :
Das ausschliessliche Vorkommen reifer rundkerniger Leukozyten bei der reingezüchteten Pelger−Huëtschen Anomalie des Kaninchens und die Bedeutung der Pelger−Leukozyten in der vergleichenden Hämatologie. Folia Haemat. 67:249−291, 1943.
1939 Undritz, E. :
Das Pelger-Huetsche Blutbild beim Tier und seine Bedeutung fiir die Entwicklungsgeschichte des Blutes Schweizerische medizinische Wochenschrift 69:1177-1186, 1939.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 28 Apr 2016
  • Changed by Frank Nicholas on 02 May 2016
  • Changed by Tosso Leeb on 26 May 2020
  • Changed by Imke Tammen2 on 23 Nov 2022