OMIA 000975-9940 : Tail, short in Ovis aries
Han et al. (2019) reported that "one missense mutation, c.334G>T (GGG>TGG) [which appears to be the same variant reported by Zhi et al. (2018)] with a completely linked [adjacent] synonymous variant c.333G>C (CCG>CCC) [both in the TBXT gene, previously known as the T gene] was found to be associated with the ‘tailless’ characteristic in typical fat‐rumped sheep breeds".
In neither paper do the authors appear to be concluding that the named variants should be listed as likely causal variants.Associated gene:
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|T||T brachyury transcription factor||Ovis aries||8||NC_040259.1 (95880321..95870853)||T||Homologene, Ensembl, NCBI gene|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2019||Han, J., Yang, M., Guo, T., Niu, C., Liu, J., Yue, Y., Yuan, C., Yang, B., Han, J., Yang, M., Guo, T., Niu, C., Liu, J., Yue, Y., Yuan, C., Yang, B. :|
|Two linked TBXT (brachyury) gene polymorphisms are associated with the tailless phenotype in fat-rumped sheep. Anim Genet 50:772-777, 2019. Pubmed reference: 31475743. DOI: 10.1111/age.12852.|
|2018||Zhi, D., Da, L., Liu, M., Cheng, C., Zhang, Y., Wang, X., Li, X., Tian, Z., Yang, Y., He, T., Long, X., Wei, W., Cao, G. :|
|Whole Genome Sequencing of Hulunbuir Short-Tailed Sheep for Identifying Candidate Genes Related to the Short-Tail Phenotype. G3 (Bethesda) 8:377-383, 2018. Pubmed reference: 29208649. DOI: 10.1534/g3.117.300307.|
|1991||James, P.J., Gare, D.R., Singh, A.W., Clark, J.P., Ponzoni, R.W., Ancell, P.M. :|
|Studies of the Potential for Breeding Short Tail Merinos Wool Technology and Sheep Breeding 38:106-111, 1991.|
|James, P.J., Ponzoni, R.W., Gare, D.R., Cockrum, K.S. :|
|Inheritance of short tailedness in South Australian Merinos Proceedings of the Australian Association of Animal Breeding and Genetics 9:404-407, 1991.|
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 10 Sep 2019