OMIA:000975-9940 : Tail, short in Ovis aries

In other species: dog , cattle , domestic cat , Asiatic golden cat

Categories: Limbs / digit / tail phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 601397 (gene) , 615709 (trait) , 182940 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Also called brachyury

Species-specific description: There is hope that this trait may provide a form of natural resistance to the sheep blowfly.

Molecular basis: Zhi et al. (2018) reported that "a nonsynonymous mutation at c.G334T [in the TBXT gene, previously known as the T gene] resulted in p.G112W substitution." These authors "inferred that the c.G334T mutation in T leads to functional changes in Brachyury—encoded by this gene—resulting in the short-tail phenotype" in the Hulunbuir short‐tailed breed.

Han et al. (2019) reported that "one missense mutation, c.334G>T (GGG>TGG) [which appears to be the same variant reported by Zhi et al. (2018)] with a completely linked [adjacent] synonymous variant c.333G>C (CCG>CCC) [both in the TBXT gene, previously known as the T gene] was found to be associated with the ‘tailless’ characteristic in typical fat‐rumped sheep breeds".

In neither paper do the authors appear to be concluding that the named variants should be listed as likely causal variants.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
T T brachyury transcription factor Ovis aries 8 NC_056061.1 (88883202..88872947) T Homologene, Ensembl , NCBI gene


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Hümmelchen, H., Wenisch, S., Brügemann, K., König, S., Wagner, H. :
[Phenotyping the sheep tail - Presentation of characterization methods in the context of breeding for short-tailedness]. Tierarztl Prax Ausg G Grosstiere Nutztiere 51:6-14, 2023. Pubmed reference: 36913936 . DOI: 10.1055/a-2007-1483.
2021 Kalds, P., Luo, Q., Sun, K., Zhou, S., Chen, Y., Wang, X. :
Trends towards revealing the genetic architecture of sheep tail patterning: Promising genes and investigatory pathways. Anim Genet 52:799-812, 2021. Pubmed reference: 34472112 . DOI: 10.1111/age.13133.
2020 Amane, A., Belay, G., Nasser, Y., Kyalo, M., Dessie, T., Kebede, A., Getachew, T., Entfellner, J.D., Edea, Z., Hanotte, O., Tarekegn, G.M. :
Genome-wide insights of Ethiopian indigenous sheep populations reveal the population structure related to tail morphology and phylogeography. Genes Genomics 42:1169-1178, 2020. Pubmed reference: 32803704 . DOI: 10.1007/s13258-020-00984-y.
Zhao, F., Deng, T., Shi, L., Wang, W., Zhang, Q., Du, L., Wang, L. :
Genomic scan for selection signature reveals fat deposition in Chinese indigenous sheep with extreme tail types. Animals (Basel) 10:773, 2020. Pubmed reference: 32365604 . DOI: 10.3390/ani10050773.
2019 Han, J., Yang, M., Guo, T., Niu, C., Liu, J., Yue, Y., Yuan, C., Yang, B., Han, J., Yang, M., Guo, T., Niu, C., Liu, J., Yue, Y., Yuan, C., Yang, B. :
Two linked TBXT (brachyury) gene polymorphisms are associated with the tailless phenotype in fat-rumped sheep. Anim Genet 50:772-777, 2019. Pubmed reference: 31475743 . DOI: 10.1111/age.12852.
2018 Ahbara, A., Bahbahani, H., Almathen, F., Al Abri, M., Agoub, M.O., Abeba, A., Kebede, A., Musa, H.H., Mastrangelo, S., Pilla, F., Ciani, E., Hanotte, O., Mwacharo, J.M. :
Genome-wide variation, candidate regions and genes associated with fat deposition and tail morphology in Ethiopian indigenous sheep. Front Genet 9:699, 2018. Pubmed reference: 30687385 . DOI: 10.3389/fgene.2018.00699.
Zhi, D., Da, L., Liu, M., Cheng, C., Zhang, Y., Wang, X., Li, X., Tian, Z., Yang, Y., He, T., Long, X., Wei, W., Cao, G. :
Whole Genome Sequencing of Hulunbuir Short-Tailed Sheep for Identifying Candidate Genes Related to the Short-Tail Phenotype. G3 (Bethesda) 8:377-383, 2018. Pubmed reference: 29208649 . DOI: 10.1534/g3.117.300307.
1991 James, P.J., Gare, D.R., Singh, A.W., Clark, J.P., Ponzoni, R.W., Ancell, P.M. :
Studies of the Potential for Breeding Short Tail Merinos Wool Technology and Sheep Breeding 38:106-111, 1991.
James, P.J., Ponzoni, R.W., Gare, D.R., Cockrum, K.S. :
Inheritance of short tailedness in South Australian Merinos Proceedings of the Australian Association of Animal Breeding and Genetics 9:404-407, 1991.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 10 Sep 2019