OMIA:001206-9615 : Laryngeal paralysis, generic in Canis lupus familiaris (dog)

In other species: horse , taurine cattle

Categories: Respiratory system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

History: Variants in several genes have been associated with forms of polyneuropathy and/or laryngeal paralysis in various breeds: OMIA 001917-9615 (ARHGEF10), OMIA 002119-9615 (GJA9), OMIA 001970-9615 (RAB3GAP1), OMIA 002284-9615 (SBF2), OMIA 002222-9615 (RAPGEF6) and OMIA 002301-9615 (CNTNAP1). References relating to other polyneuropathies with laryngeal paralysis in dogs without known genetic associations are listed under OMIA 001292-9615.

Mapping: Srikanth et al. (2022): "Using a genome-wide association study (GWAS), we identified a 708 kb region on CFA 18 harboring 226 SNPs to be significantly associated with CLP [in Alaskan Sled dogs]. The significant SNPs explained 47.06% of the heritability of CLP. We narrowed the region to 431 kb through autozygosity mapping and found 18 of the 20 cases to be homozygous for the risk haplotype. Whole genome sequencing of two cases and a control ASD, and comparison with the genome of 657 dogs from various breeds, confirmed the homozygous status of the risk haplotype to be unique to the CLP cases."

Molecular basis: Holt et al. (2016) concluded that "Mutations in the DCTN1 gene did not appear to cause laryngeal paralysis in Leonbergers or Labrador Retrievers"

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Dalmatian (Dog) (VBO_0200427), Labrador Retriever (Dog) (VBO_0200800), obsolete Alaskan Sled Dog (Dog) (VBO_0200019), Pyrenean Mountain Dog (Dog) (VBO_0201113), Rottweiler (Dog) (VBO_0201143).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:001206-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2022 Srikanth, K., von Pfeil, D.J.F., Stanley, B.J., Griffitts, C., Huson, H.J. :
Genome Wide Association Study with Imputed Whole Genome Sequence Data Identifies a 431 kb Risk Haplotype on CFA18 for Congenital Laryngeal Paralysis in Alaskan Sled Dogs. Genes (Basel) 13, 2022. Pubmed reference: 36292693. DOI: 10.3390/genes13101808.
2018 von Pfeil, D.J.F., Zellner, E., Fritz, M.C., Langohr, I., Griffitts, C., Stanley, B.J. :
Congenital laryngeal paralysis in Alaskan Huskies: 25 cases (2009-2014). J Am Vet Med Assoc 253:1057-1065, 2018. Pubmed reference: 30272513. DOI: 10.2460/javma.253.8.1057.
2016 Holt, D.E., Brown, D.C., Henthorn, P.S. :
Evaluation of the dynactin 1 gene in Leonbergers and Labrador Retrievers with laryngeal paralysis. Am J Vet Res 77:1114-20, 2016. Pubmed reference: 27668583. DOI: 10.2460/ajvr.77.10.1114.
Monnet, E. :
Surgical treatment of laryngeal paralysis. Vet Clin North Am Small Anim Pract 46:709-17, 2016. Pubmed reference: 26947115. DOI: 10.1016/j.cvsm.2016.02.003.
2013 Kitshoff, A.M., Van Goethem, B., Stegen, L., Vandekerckhov, P., de Rooster, H. :
Laryngeal paralysis in dogs: an update on recent knowledge. J S Afr Vet Assoc 84:E1-9, 2013. Pubmed reference: 23718178.
2011 Granger, N. :
Canine inherited motor and sensory neuropathies: an updated classification in 22 breeds and comparison to Charcot-Marie-Tooth disease. Vet J 188:274-85, 2011. Pubmed reference: 20638305. DOI: 10.1016/j.tvjl.2010.06.003.
2006 Gabriel, A., Poncelet, L., Van Ham, L., Clercx, C., Braund, KG., Bhatti, S., Detilleux, J., Peeters, D. :
Laryngeal paralysis-polyneuropathy complex in young related Pyrenean mountain dogs. J Small Anim Pract 47:144-9, 2006. Pubmed reference: 16512846. DOI: 10.1111/j.1748-5827.2006.00058.x.
2001 Griffiths, L.G., Sullivan, M., Reid, S.W.J. :
A comparison of the effects of unilateral thyroarytenoid lateralization versus cricoarytenoid laryngoplasty on the area of the rima glottidis and clinical outcome in dogs with laryngeal paralysis Veterinary Surgery 30:359-365, 2001. Pubmed reference: 11443597.
1998 Mahony, O.H., Knowles, K.E., Braund, K.G., Averill, D.R., Frimberger, A.E. :
Laryngeal paralysis-polyneuropathy complex in young Rottweilers Journal of Veterinary Internal Medicine 12:330-337, 1998. Pubmed reference: 9773408.
1995 Burbidge, H.M. :
A review of laryngeal paralysis in dogs. British Veterinary Journal 151:71-82, 1995. Pubmed reference: 7735872.
Kriegleder, H. :
Laryngeal paralysis in a 10-week-old Rottweiler puppy - case report [German] Praktische Tierarzt 76:1075-1076, 1995.
1994 Braund, K.G., Shores, A., Cochrane, S., Forrester, D., Kwiecien, J.M., Steiss, J.E. :
Laryngeal paralysis-polyneuropathy complex in young dalmatians. American Journal of Veterinary Research 55:534-542, 1994. Pubmed reference: 8017700.
1986 O'Brien, J.A., Hendriks, J. :
Inherited laryngeal paralysis. Analysis in the husky cross. Vet Q 8:301-2, 1986. Pubmed reference: 3798712. DOI: 10.1080/01652176.1986.9694059.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 17 Oct 2016
  • Changed by Imke Tammen2 on 11 Dec 2020
  • Changed by Imke Tammen2 on 26 Nov 2022