OMIA 001206-9615 : Laryngeal paralysis, generic in Canis lupus familiaris

In other species: horse , cattle

Mendelian trait/disorder: unknown

Considered a defect: yes

History: Variants in several genes have been associated with forms of polyneuropathy and/or laryngeal paralysis in various breeds: OMIA 001917-9615 (ARHGEF10), OMIA 002119-9615 (GJA9), OMIA 001970-9615 (RAB3GAP1), OMIA 002284-9615 (SBF2), OMIA 002222-9615 (RAPGEF6) and OMIA 002301-9615 (CNTNAP1). References relating to other polyneuropathies with laryngeal paralysis in dogs without known genetic associations are listed under OMIA 001292-9615.

Molecular basis: Holt et al. (2016) concluded that "Mutations in the DCTN1 gene did not appear to cause laryngeal paralysis in Leonbergers or Labrador Retrievers"


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2016 Holt, D.E., Brown, D.C., Henthorn, P.S. :
Evaluation of the dynactin 1 gene in Leonbergers and Labrador Retrievers with laryngeal paralysis. Am J Vet Res 77:1114-20, 2016. Pubmed reference: 27668583. DOI: 10.2460/ajvr.77.10.1114.
Monnet, E. :
Surgical treatment of laryngeal paralysis. Vet Clin North Am Small Anim Pract 46:709-17, 2016. Pubmed reference: 26947115. DOI: 10.1016/j.cvsm.2016.02.003.
2013 Kitshoff, A.M., Van Goethem, B., Stegen, L., Vandekerckhov, P., de Rooster, H. :
Laryngeal paralysis in dogs: an update on recent knowledge. J S Afr Vet Assoc 84:E1-9, 2013. Pubmed reference: 23718178.
2011 Granger, N. :
Canine inherited motor and sensory neuropathies: an updated classification in 22 breeds and comparison to Charcot-Marie-Tooth disease. Vet J 188:274-85, 2011. Pubmed reference: 20638305. DOI: 10.1016/j.tvjl.2010.06.003.
2006 Gabriel, A., Poncelet, L., Van Ham, L., Clercx, C., Braund, KG., Bhatti, S., Detilleux, J., Peeters, D. :
Laryngeal paralysis-polyneuropathy complex in young related Pyrenean mountain dogs. J Small Anim Pract 47:144-9, 2006. Pubmed reference: 16512846. DOI: 10.1111/j.1748-5827.2006.00058.x.
2001 Griffiths, L.G., Sullivan, M., Reid, S.W.J. :
A comparison of the effects of unilateral thyroarytenoid lateralization versus cricoarytenoid laryngoplasty on the area of the rima glottidis and clinical outcome in dogs with laryngeal paralysis Veterinary Surgery 30:359-365, 2001. Pubmed reference: 11443597.
1998 Mahony, O.H., Knowles, K.E., Braund, K.G., Averill, D.R., Frimberger, A.E. :
Laryngeal paralysis-polyneuropathy complex in young Rottweilers Journal of Veterinary Internal Medicine 12:330-337, 1998. Pubmed reference: 9773408.
1995 Burbidge, H.M. :
A Review of Laryngeal Paralysis in Dogs British Veterinary Journal 151:71-82, 1995. Pubmed reference: 7735872.
Kriegleder, H. :
Laryngeal paralysis in a 10-week-old Rottweiler puppy - case report [German] Praktische Tierarzt 76:1075-1076, 1995.
1994 Braund, K.G., Shores, A., Cochrane, S., Forrester, D., Kwiecien, J.M., Steiss, J.E. :
Laryngeal Paralysis-Polyneuropathy Complex in Young Dalmatians American Journal of Veterinary Research 55:534-542, 1994. Pubmed reference: 8017700.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 17 Oct 2016
  • Changed by Imke Tammen2 on 11 Dec 2020