OMIA:001283-9615 : Xanthinuria, generic in Canis lupus familiaris (dog)

In other species: giant otter , domestic cat , taurine cattle , goat

Categories: Renal / urinary system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 278300 (trait) , 603592 (trait)

Mendelian trait/disorder: unknown

Mode of inheritance: Probably autosomal recessive

Considered a defect: yes

Cross-species summary: Animals with hereditary xanthinuria (excretion of large amounts of xanthine in the urine) may be asymptomatic, may have subclinical uroliths (xanthine stones), or present with clinical signs of urolithiasis. Urolith formation can be influenced by other biologic and environmental factors such as sex, diet and urine properties. Xanthinuria, type I (OMIA:002445) is caused by variation in the XDH gene and xanthinuria, type II (OMIA:001819) is caused by variation in the MOCOS gene. Information relating to xanthinuria without identified causal variants is listed under xanthinuria, generic (OMIA:001283).

Species-specific description: See also Xanthinuria type I and type II specific entries.

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:001283-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2013 Jacinto, A.M., Mellanby, R.J., Chandler, M., Bommer, N.X., Carruthers, H., Fairbanks, L.D., Gow, A.G. :
Urine concentrations of xanthine, hypoxanthine and uric acid in UK Cavalier King Charles spaniels. J Small Anim Pract 54:395-8, 2013. Pubmed reference: 23859747. DOI: 10.1111/jsap.12106.
2011 Gow, A.G., Fairbanks, L.D., Simpson, J.W., Jacinto, A.M., Ridyard, A.E. :
Xanthine urolithiasis in a Cavalier King Charles spaniel. Vet Rec 169:209, 2011. Pubmed reference: 21742684. DOI: 10.1136/vr.d3932.
1998 Flegel, T., Freistadt, R., Haider, W. :
Xanthine urolithiasis in a dachshund Veterinary Record 143:420-423, 1998. Pubmed reference: 9807792.
1997 Kucera, J., Bulkova, T., Rychla, R., Jahn, P. :
Bilateral xanthine nephrolithiasis in a dog Journal of Small Animal Practice 38:302-305, 1997. Pubmed reference: 9239633.
Vanzuilen, C.D., Nickel, R.F., Vandijk, T.H., Reijngoud, D.J. :
Xanthinuria in a family of Cavalier King Charles spaniels Veterinary Quarterly 19:172-174, 1997. Pubmed reference: 9413115.
1996 van Zuilen, C.D., Nickel, R.F., van Dijk, T.H., Reijngoud, D.J. :
Xanthinuria (xanthine oxidase deficiency) in two Cavalier King Charles spaniels Veterinary Quarterly 18:S 24-S 25, 1996.
1969 Delbarre, F., Holtzer, A., Auscher, C. :
[Xanthine urinary lithiasis and xanthinuria in a dachshund. Deficiency, probably genetic, of the xanthine oxidase system]. C R Acad Hebd Seances Acad Sci D 269:1449-52, 1969. Pubmed reference: 4982510.
1968 Kidder, D.E., Chivers, P.R. :
Xanthine calculi in a dog. Vet Rec 83:228-9, 1968. Pubmed reference: 5212505. DOI: 10.1136/vr.83.9.228.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 05 Aug 2013
  • Changed by Imke Tammen2 on 02 Nov 2020
  • Changed by Imke Tammen2 on 03 Oct 2021