OMIA:001283-9685 : Xanthinuria, generic in Felis catus (domestic cat)
Categories: Renal / urinary system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Cross-species summary: Animals with hereditary xanthinuria (excretion of large amounts of xanthine in the urine) may be asymptomatic, may have subclinical uroliths (xanthine stones), or present with clinical signs of urolithiasis. Urolith formation can be influenced by other biologic and environmental factors such as sex, diet and urine properties. Xanthinuria, type I (OMIA002445) is caused by variation in the XDH gene and xanthinuria, type II (OMIA 001819) is caused by variation in the MOCOS gene. Information relating to xanthinuria without identified causal variants is listed under xanthinuria, generic (OMIA 001283).
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2015||Furman, E., Hooijberg, E.H., Leidinger, E., Zedinger, C., Giger, U., Leidinger, J. :|
|Hereditary xanthinuria and urolithiasis in a domestic shorthair cat. Comp Clin Path 24:1325-1329, 2015. Pubmed reference: 26478726. DOI: 10.1007/s00580-015-2072-5.|
|2013||Mestrinho, L.A., Gonçalves, T., Parreira, P.B., Niza, M.M., Hamaide, A.J. :|
|Xanthine urolithiasis causing bilateral ureteral obstruction in a 10-month-old cat. J Feline Med Surg 15:911-6, 2013. Pubmed reference: 23413269. DOI: 10.1177/1098612X13477413.|
|2009||Schweighauser, A., Howard, J., Malik, Y., Francey, T. :|
|Xanthinuria in a domestic shorthair cat. Vet Rec 164:91-2, 2009. Pubmed reference: 19151408. DOI: 10.1136/vr.164.3.91.|
|2007||Tsuchida, S., Kagi, A., Koyama, H., Tagawa, M. :|
|Xanthine urolithiasis in a cat: a case report and evaluation of a candidate gene for xanthine dehydrogenase. J Feline Med Surg 9:503-8, 2007. Pubmed reference: 17576085. DOI: 10.1016/j.jfms.2007.03.012.|
|1997||White, R.N., Tick, N.T., White, H.L. :|
|Naturally occurring xanthine urolithiasis in a domestic shorthair cat Journal of Small Animal Practice 38:299-301, 1997. Pubmed reference: 9239632.|
- Created by Frank Nicholas on 06 Sep 2005