OMIA:001292-9615 : Polyneuropathy, generic in Canis lupus familiaris (dog)

In other species: domestic cat

Categories: Nervous system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 601455 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: yes

Key variant known: no

History: Variants in other several have been associated with other forms of polyneuropathy and/or laryngeal paralysis in various breeds, for example OMIA 001917-9615 (ARHGEF10), OMIA 002119-9615 (GJA9), OMIA 001970-9615 (RAB3GAP1), OMIA 002284-9615 (SBF2), OMIA 002301-9615 (CNTNAP1), OMIA 002222-9615 (RAPGEF6), OMIA 002727-9615 (MTMR2), OMIA 002739-9615 (MPZ) and OMIA 002740-9615 (SH3TC2). References relating to laryngeal paralysis in dogs without known genetic associations are listed under OMIA 001206-9615.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Alaskan Malamute (Dog) (VBO_0200017), American Staffordshire Terrier (Dog) (VBO_0200055), Border Collie (Dog) (VBO_0200193), Dalmatian (Dog) (VBO_0200427), Golden Retriever (Dog) (VBO_0200610), Greyhound (Dog) (VBO_0200638), Leonberger (Dog) (VBO_0200819), Miniature Schnauzer (Dog) (VBO_0200896), Pyrenean Mountain Dog (Dog) (VBO_0201113), Rottweiler (Dog) (VBO_0201143).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001292-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2018 Vandenberghe, H., Escriou, C., Rosati, M., Porcarelli, L., Recio Caride, A., Añor, S., Gandini, G., Corlazzoli, D., Thibaud, J.L., Matiasek, K., Blot, S. :
Juvenile-onset polyneuropathy in American Staffordshire Terriers. J Vet Intern Med 32:2003-2012, 2018. Pubmed reference: 30315663. DOI: 10.1111/jvim.15316.
2011 Granger, N. :
Canine inherited motor and sensory neuropathies: an updated classification in 22 breeds and comparison to Charcot-Marie-Tooth disease. Vet J 188:274-85, 2011. Pubmed reference: 20638305. DOI: 10.1016/j.tvjl.2010.06.003.
Matiasek, K., Drögemüller, C. :
Charcot-Marie-Tooth disease: inherited neuropathies revisited. Vet J 188:254-5, 2011. Pubmed reference: 21459024. DOI: 10.1016/j.tvjl.2011.03.002.
2006 Gabriel, A., Poncelet, L., Van Ham, L., Clercx, C., Braund, KG., Bhatti, S., Detilleux, J., Peeters, D. :
Laryngeal paralysis-polyneuropathy complex in young related Pyrenean mountain dogs. J Small Anim Pract 47:144-9, 2006. Pubmed reference: 16512846. DOI: 10.1111/j.1748-5827.2006.00058.x.
2004 Coates, JR., O'Brien, DP. :
Inherited peripheral neuropathies in dogs and cats. Vet Clin North Am Small Anim Pract 34:1361-401, 2004. Pubmed reference: 15474679. DOI: 10.1016/j.cvsm.2004.05.011.
2003 Shelton, G.D., Podell, M., Poncelet, L., Schatzberg, S., Patterson, E., Powell, H.C., Mizisin, A.P. :
Inherited polyneuropathy in Leonberger dogs: a mixed or intermediate form of Charcot-Marie-Tooth disease? Muscle & Nerve 27:471-7, 2003. Pubmed reference: 12661049. DOI: 10.1002/mus.10350.
1998 Mahony, O.H., Knowles, K.E., Braund, K.G., Averill, D.R., Frimberger, A.E. :
Laryngeal paralysis-polyneuropathy complex in young Rottweilers Journal of Veterinary Internal Medicine 12:330-337, 1998. Pubmed reference: 9773408.
1997 Vanham, L., Braund, K.G., Roels, S., Putcuyps, I. :
Treatment of a dog with an insulinoma-related peripheral polyneuropathy with corticosteroids Veterinary Record 141:98-100, 1997. Pubmed reference: 9265710.
1996 Schrauwen, E., Vanham, L., Desmidt, M., Hoorens, J. :
Peripheral polyneuropathy associated with insulinoma in the dog - clinical, pathological, and electrodiagnostic features Progress in Veterinary Neurology 7:16-19, 1996.
1994 Braund, K.G., Shores, A., Cochrane, S., Forrester, D., Kwiecien, J.M., Steiss, J.E. :
Laryngeal paralysis-polyneuropathy complex in young dalmatians. American Journal of Veterinary Research 55:534-542, 1994. Pubmed reference: 8017700.
1990 Matz, M.E., Shell, L., Braund, K. :
Peripheral hypomyelinization in 2 Golden Retriever littermates. Journal of the American Veterinary Medical Association 197:228-230, 1990. Pubmed reference: 2166727.
1989 Braund, K.G., Mehta, J.R., Toiviokinnucan, M., Amling, K.A., Shell, L.G., Matz, M.E. :
Congenital hypomyelinating polyneuropathy in 2 Golden Retriever littermates. Veterinary Pathology 26:202-208, 1989. Pubmed reference: 2548315.

Edit History

  • Created by Frank Nicholas on 15 Jul 2010
  • Changed by Frank Nicholas on 28 Sep 2011
  • Changed by Frank Nicholas on 12 Dec 2011
  • Changed by Frank Nicholas on 29 Jun 2012
  • Changed by Frank Nicholas on 10 Feb 2013
  • Changed by Tosso Leeb on 29 May 2013
  • Changed by Frank Nicholas on 27 Aug 2016
  • Changed by Frank Nicholas on 12 May 2017
  • Changed by Frank Nicholas on 31 Aug 2017
  • Changed by Imke Tammen2 on 11 Dec 2020
  • Changed by Imke Tammen2 on 22 Jul 2023