OMIA:001292-9615 : Polyneuropathy, generic in Canis lupus familiaris (dog)

In other species: domestic cat

Categories: Nervous system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 601455 (trait)

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: yes

Key variant known: no

History: Variants in other several have been associated with other forms of polyneuropathy and/or laryngeal paralysis in various breeds, for example OMIA:001917-9615 (ARHGEF10), OMIA:002119-9615 (GJA9), OMIA:001970-9615 (RAB3GAP1), OMIA:002284-9615 (SBF2), OMIA:002301-9615 (CNTNAP1), OMIA:002222-9615 (RAPGEF6), OMIA:002727-9615 (MTMR2), OMIA:002739-9615 (MPZ) and OMIA:002740-9615 (SH3TC2). References relating to laryngeal paralysis in dogs without known genetic associations are listed under OMIA:001206-9615.

Breeds: Alaskan Malamute (Dog) (VBO_0200017), American Staffordshire Terrier (Dog) (VBO_0200055), Border Collie (Dog) (VBO_0200193), Dalmatian (Dog) (VBO_0200427), Golden Retriever (Dog) (VBO_0200610), Greyhound (Dog) (VBO_0200638), Leonberger (Dog) (VBO_0200819), Miniature Schnauzer (Dog) (VBO_0200896), Pyrenean Mountain Dog (Dog) (VBO_0201113), Rottweiler (Dog) (VBO_0201143).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:001292-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Anderson, R.S., Chu, A.K., Rylander, H., Binversie, E.E., Duncan, I.D., Baker, L., Salamat, S., Patterson, M.M., Gruel, J., Kohler, N.L., Kearney, H.K., Ale, S.M., Momen, M.M., Muir, P., Svaren, J.P., Johnson, R., Sample, S.J. :
Pathologic classification of a late-onset peripheral neuropathy in a spontaneous Labrador retriever dog model. J Comp Neurol 532:e25596, 2024. Pubmed reference: 38439568. DOI: 10.1002/cne.25596.
2018 Vandenberghe, H., Escriou, C., Rosati, M., Porcarelli, L., Recio Caride, A., Añor, S., Gandini, G., Corlazzoli, D., Thibaud, J.L., Matiasek, K., Blot, S. :
Juvenile-onset polyneuropathy in American Staffordshire Terriers. J Vet Intern Med 32:2003-2012, 2018. Pubmed reference: 30315663. DOI: 10.1111/jvim.15316.
2011 Granger, N. :
Canine inherited motor and sensory neuropathies: an updated classification in 22 breeds and comparison to Charcot-Marie-Tooth disease. Vet J 188:274-85, 2011. Pubmed reference: 20638305. DOI: 10.1016/j.tvjl.2010.06.003.
Matiasek, K., Drögemüller, C. :
Charcot-Marie-Tooth disease: inherited neuropathies revisited. Vet J 188:254-5, 2011. Pubmed reference: 21459024. DOI: 10.1016/j.tvjl.2011.03.002.
2006 Gabriel, A., Poncelet, L., Van Ham, L., Clercx, C., Braund, KG., Bhatti, S., Detilleux, J., Peeters, D. :
Laryngeal paralysis-polyneuropathy complex in young related Pyrenean mountain dogs. J Small Anim Pract 47:144-9, 2006. Pubmed reference: 16512846. DOI: 10.1111/j.1748-5827.2006.00058.x.
2004 Coates, JR., O'Brien, DP. :
Inherited peripheral neuropathies in dogs and cats. Vet Clin North Am Small Anim Pract 34:1361-401, 2004. Pubmed reference: 15474679. DOI: 10.1016/j.cvsm.2004.05.011.
2003 Shelton, G.D., Podell, M., Poncelet, L., Schatzberg, S., Patterson, E., Powell, H.C., Mizisin, A.P. :
Inherited polyneuropathy in Leonberger dogs: a mixed or intermediate form of Charcot-Marie-Tooth disease? Muscle & Nerve 27:471-7, 2003. Pubmed reference: 12661049. DOI: 10.1002/mus.10350.
1998 Mahony, O.H., Knowles, K.E., Braund, K.G., Averill, D.R., Frimberger, A.E. :
Laryngeal paralysis-polyneuropathy complex in young Rottweilers Journal of Veterinary Internal Medicine 12:330-337, 1998. Pubmed reference: 9773408.
1997 Vanham, L., Braund, K.G., Roels, S., Putcuyps, I. :
Treatment of a dog with an insulinoma-related peripheral polyneuropathy with corticosteroids Veterinary Record 141:98-100, 1997. Pubmed reference: 9265710.
1996 Schrauwen, E., Vanham, L., Desmidt, M., Hoorens, J. :
Peripheral polyneuropathy associated with insulinoma in the dog - clinical, pathological, and electrodiagnostic features Progress in Veterinary Neurology 7:16-19, 1996.
1994 Braund, K.G., Shores, A., Cochrane, S., Forrester, D., Kwiecien, J.M., Steiss, J.E. :
Laryngeal paralysis-polyneuropathy complex in young dalmatians. American Journal of Veterinary Research 55:534-542, 1994. Pubmed reference: 8017700.
1990 Matz, M.E., Shell, L., Braund, K. :
Peripheral hypomyelinization in 2 Golden Retriever littermates. Journal of the American Veterinary Medical Association 197:228-230, 1990. Pubmed reference: 2166727.
1989 Braund, K.G., Mehta, J.R., Toiviokinnucan, M., Amling, K.A., Shell, L.G., Matz, M.E. :
Congenital hypomyelinating polyneuropathy in 2 Golden Retriever littermates. Veterinary Pathology 26:202-208, 1989. Pubmed reference: 2548315.

Edit History

  • Created by Frank Nicholas on 15 Jul 2010
  • Changed by Frank Nicholas on 28 Sep 2011
  • Changed by Frank Nicholas on 12 Dec 2011
  • Changed by Frank Nicholas on 29 Jun 2012
  • Changed by Frank Nicholas on 10 Feb 2013
  • Changed by Tosso Leeb on 29 May 2013
  • Changed by Frank Nicholas on 27 Aug 2016
  • Changed by Frank Nicholas on 12 May 2017
  • Changed by Frank Nicholas on 31 Aug 2017
  • Changed by Imke Tammen2 on 11 Dec 2020
  • Changed by Imke Tammen2 on 22 Jul 2023
  • Changed by Imke Tammen2 on 09 Feb 2024