OMIA 001302-9031 : Resistance to avian sarcoma and leukosis viruses, subgroup B in Gallus gallus

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2002

Species-specific name: tvb locus

Species-specific symbol: tvb

Species-specific description: As in many other cases of single-locus resistance, resistance to type B avian leukosis viruses is due to the lack of a functional receptor for the viruses.

Inheritance: Resistance to the B subgroup of avian sarcoma and leukosis viruses is a single-locus trait, with susceptibility being dominant and resistance recessive (Crittenden et al. 1967), who named the locus "tumour virus b" (tvb).

Molecular basis: By cloning and sequencing a very likely candidate gene (based on knowledge of the receptor that results in susceptibility), Klucking et al. (2002) reported that the tvb gene "is a tumor necrosis factor receptor (TNFR)-related death receptor that is most similar to the mammalian TNF-related apoptosis-inducing ligand (TRAIL) receptors DR4 and DR5". They also showed that resistance is due to a nonsense mutation (C172T) that results in a "severely truncated protein product". The TVB gene is now known as TNFRSF10B.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b Gallus gallus 22 NC_006109.5 (1415452..1421965) TNFRSF10B Homologene, Ensembl, NCBI gene

Variants

By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.

WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
Resistance to avian sarcoma and leukosis viruses, subgroup B TNFRSF10B missense c.G>C p.C125S 2008 18094190
Resistance to avian sarcoma and leukosis viruses, subgroup B TNFRSF10B nonsense (stop-gain) Gallus_gallus-5.0 22 g.1281321C>T c.172C>T p.Q58* rs736008824 2002 12097608 Variant coordinates obtained from or confirmed by EBI's Some Effect Predictor (VEP) tool

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2011 Yang, J., Yu, Y., Yao, J., Chen, Y., Xu, G., Yang, N., Sun, D., Zhang, Y. :
Molecular identification of avian leukosis virus subgroup E loci and tumor virus B locus in Chinese indigenous chickens. Poult Sci 90:759-65, 2011. Pubmed reference: 21406360. DOI: 10.3382/ps.2010-01133.
2009 Asimakopoulos, F., Varmus, H.E. :
Cell-specific transduction of Prdm1-expressing lineages mediated by a receptor for avian leukosis virus subgroup B. J Virol 83:4835-43, 2009. Pubmed reference: 19279099. DOI: 10.1128/JVI.02254-08.
2008 Hunt, H., Fadly, A., Silva, R., Zhang, H. :
Survey of endogenous virus and TVB* receptor status of commercial chicken stocks supplying specific-pathogen-free eggs. Avian Dis 52:433-40, 2008. Pubmed reference: 18939631.
Reinisov√°, M., Senigl, F., Yin, X., Plachy, J., Geryk, J., Elleder, D., Svoboda, J., Federspiel, M.J., Hejnar, J. :
A single-amino-acid substitution in the TvbS1 receptor results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo. J Virol 82:2097-105, 2008. Pubmed reference: 18094190. DOI: 10.1128/JVI.02206-07.
Yu, Y., Zhang, H., Tian, F., Bacon, L., Zhang, Y., Zhang, W., Song, J. :
Quantitative evaluation of DNA methylation patterns for ALVE and TVB genes in a neoplastic disease susceptible and resistant chicken model. PLoS One 3:e1731, 2008. Pubmed reference: 18320050. DOI: 10.1371/journal.pone.0001731.
2007 Zhang, H.M., Bacon, L.D., Heidari, M., Muir, W.M., Groenen, M.A., Zhang, Y., Wong, G.K., Fulton, J.E., O'Sullivan, N.P., Albers, G.A., Vereijken, A.L., Rattink, A.P., Okimoto, R., McKay, J.C., McLeod, S., Cheng, H.H. :
Genetic variation at the tumour virus B locus in commercial and laboratory chicken populations assessed by a medium-throughput or a high-throughput assay. Avian Pathol 36:283-91, 2007. Pubmed reference: 17620174. DOI: 10.1080/03079450701449248.
2005 Zhang, H.M., Bacon, L.D., Cheng, H.H., Hunt, H.D. :
Development and validation of a PCR-RFLP assay to evaluate TVB haplotypes coding receptors for subgroup B and subgroup E avian leukosis viruses in White Leghorns. Avian Pathol 34:324-31, 2005. Pubmed reference: 16147569. DOI: 10.1080/03079450500179491.
2004 Klucking, S., Young, J.A. :
Amino acid residues Tyr-67, Asn-72, and Asp-73 of the TVB receptor are important for subgroup E avian sarcoma and leukosis virus interaction. Virology 318:371-80, 2004. Pubmed reference: 14972562. DOI: 10.1016/j.virol.2003.09.024.
2002 Chi, Y., Diaz-Griffero, F., Wang, C., Young, J.A., Brojatsch, J. :
An NF-kappa B-dependent survival pathway protects against cell death induced by TVB receptors for avian leukosis viruses. J Virol 76:5581-7, 2002. Pubmed reference: 11991986.
Klucking, S., Adkins, H.B., Young, J.A. :
Resistance to infection by subgroups B, D, and E avian sarcoma and leukosis viruses is explained by a premature stop codon within a resistance allele of the tvb receptor gene. J Virol 76:7918-21, 2002. Pubmed reference: 12097608.
Knauss, D.J., Young, J.A. :
A fifteen-amino-acid TVB peptide serves as a minimal soluble receptor for subgroup B avian leukosis and sarcoma viruses. J Virol 76:5404-10, 2002. Pubmed reference: 11991969.
2001 Adkins, H.B., Blacklow, S.C., Young, J.A. :
Two functionally distinct forms of a retroviral receptor explain the nonreciprocal receptor interference among subgroups B, D, and E avian leukosis viruses. J Virol 75:3520-6, 2001. Pubmed reference: 11264341. DOI: 10.1128/JVI.75.8.3520-3526.2001.
2000 Adkins, H.B., Brojatsch, J., Young, J.A. :
Identification and characterization of a shared TNFR-related receptor for subgroup B, D, and E avian leukosis viruses reveal cysteine residues required specifically for subgroup E viral entry. J Virol 74:3572-78, 2000. Pubmed reference: 10729132.
Brojatsch, J., Naughton, J., Adkins, H.B., Young, J.A. :
TVB receptors for cytopathic and noncytopathic subgroups of avian leukosis viruses are functional death receptors. J Virol 74:11490-4, 2000. Pubmed reference: 11090145.
1998 Smith, E.J., Brojatsch, J., Naughton, J., Young, J.A.T. :
The CAR1 gene encoding a cellular receptor specific for subgroup b and d avian leukosis viruses maps to the chicken tvb locus Journal of Virology 72:3501-3503, 1998. Pubmed reference: 9525691.
1997 Adkins, H.B., Brojatsch, J., Naughton, J., Rolls, M.M., Pesola, J.M., Young, J.A. :
Identification of a cellular receptor for subgroup E avian leukosis virus. Proc Natl Acad Sci U S A 94:11617-22, 1997. Pubmed reference: 9326659.
1996 Brojatsch, J., Naughton, J., Rolls, M.M., Zingler, K., Young, J.A.T. :
CAR1, a tnfr-related protein, is a cellular receptor for cytopathic avian leukosis sarcoma viruses and mediates apoptosis Cell 87:845-855, 1996. Pubmed reference: 8945512.
1976 Pani, P.K. :
Further studies in genetic resistance of fowl to RSV(RAV O): evidence for interaction between independently segregating tumour virus b and tumour virus e genes. J Gen Virol 32:441-53, 1976. Pubmed reference: 184240.
1975 Crittenden, L.B., Motta, J.V. :
The role of the tvb locus in genetic resistance to RSV(RAV-O). Virology 67:327-34, 1975. Pubmed reference: 171832.
1967 Crittenden, L.B., Stone, H.A., Reamer, R.H., Okazaki, W. :
Two loci controlling genetic cellular resistance to avian leukosis-sarcoma viruses. J Virol 1:898-904, 1967. Pubmed reference: 4316238.

Edit History


  • Created by Frank Nicholas on 12 Sep 2005
  • Changed by Frank Nicholas on 01 Sep 2011
  • Changed by Frank Nicholas on 10 Oct 2011
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  • Changed by Frank Nicholas on 21 Sep 2012
  • Changed by Frank Nicholas on 21 Aug 2014