OMIA:001339-9796 : Von Willebrand disease II in Equus caballus
In other species: dog
Categories: Haematopoietic system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal
Considered a defect: yes
Key variant known: no
Cross-species summary: The von Willebrand factor (vWF) is a large multimeric plasma glycoprotein required for platelet adhesion and aggregation. A deficiency or defective vWF results in von Willebrand disease (vWD). vWD are often classified in 3 different types based on the clinical severity and quantity and multimere size of von Willebrand factor. Type I is characterized by low plasma vWF concentrations and mild to moderate bleeding symptoms. Type II disorder is characterised by qualitative abnormalities of the vWF protein and moderate to severe bleeding. Type III is the most severe form of vWD with no detectable or a severe quantitative deficiency of vWF.
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Dahlgren, A.R., Tablin, F., Finno, C.J. :|
|Genetics of equine bleeding disorders. Equine Vet J 53:30-37, 2021. Pubmed reference: 32463964 . DOI: 10.1111/evj.13290.|
|2001||Rathgeber, R.A., Brooks, M.B., Bain, F.T., Byars, T.D. :|
|Clinical vignette. Von Willebrand disease in a Thoroughbred mare and foal. J Vet Intern Med 15:63-6, 2001. Pubmed reference: 11215915 .|
|1991||Brooks, M., Leith, G.S., Allen, A.K., Woods, P.R., Benson, R.E., Dodds, W.J. :|
|Bleeding Disorder (Vonwillebrand Disease) in a Quarter Horse Journal of the American Veterinary Medical Association 198:114-116, 1991. Pubmed reference: 1995565 .|
- Created by Frank Nicholas on 23 Apr 2013