OMIA:001346-9541 : Retinal atrophy, progressive, autosomal dominant, RHO-related in Macaca fascicularis (crab-eating macaque)
In other species: dog
Categories: Vision / eye phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: yes
Key variant known: no
Cross-species summary: This disorder has been renamed in OMIA on the basis of the review by Miyadera et al. (2011)
Species-specific description: Ail et al. (2023) "developed two genetically targeted strategies using optogenetics and CRISPR-Cas9 to ablate rods and mimic rod-cone dystrophy. ... Our second model was generated by CRISPR-Cas9–mediated
disruption of the Rhodopsin gene in the rod PRs."
Cite this entry
|2023||Ail, D., Nava, D., Hwang, I.P., Brazhnikova, E., Nouvel-Jaillard, C., Dentel, A., Joffrois, C., Rousseau, L., Dégardin, J., Bertin, S., Sahel, J.A., Goureau, O., Picaud, S., Dalkara, D. :|
|Inducible nonhuman primate models of retinal degeneration for testing end-stage therapies. Sci Adv 9:eadg8163, 2023. Pubmed reference: 37531424 . DOI: 10.1126/sciadv.adg8163.|
- Created by Imke Tammen2 on 13 Aug 2023