OMIA:001360-93934 : Trimethylaminuria (fishy taint) in Coturnix japonica (Japanese quail) |
In other species: Mallard , chicken , taurine cattle
Categories: Homeostasis / metabolism phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 602079 (trait) , 136132 (gene)
Links to relevant human diseases in MONDO:
Mendelian trait/disorder: unknown
Disease-related: yes
Year key variant first reported: 2013
Molecular basis: Being well aware of the role of mutations in FMO3/FMO6P being causal for this disorder in cattle (OMIA 001360-9913) and chickens (OMIA 001360-9031), Mo et al. (2013) cloned and sequenced the quail FMO3 gene, and identified "a nonsense mutation ([c.992C>T]; Q319X) which was significantly associated with the elevated TMA content in quail egg yolks. Genotype TT at Q319X mutation loci was sensitive to choline. With addition of choline in the feed, the quails with homozygote TT at the Q319X mutation loci laid fish-odour eggs, indicating an interaction between genotype and diet. The results indicated that Q319X mutation was associated with the fishy off-flavor in quail eggs."
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| FMO3 | Coturnix coturnix | - | no genomic information (-..-) | FMO3 | Ensembl |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:001360-93934: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2013 | Mo, F., Zheng, J., Wang, P., Lian, L., Yi, G., Xu, G., Yang, N. : |
| Quail FMO3 gene cloning, tissue expression profiling, polymorphism detection and association analysis with fishy taint in eggs. PLoS One 8:e81416, 2013. Pubmed reference: 24282592. DOI: 10.1371/journal.pone.0081416. |
Edit History
- Created by Frank Nicholas on 30 Nov 2013
- Changed by Frank Nicholas on 30 Nov 2013
- Changed by Frank Nicholas on 01 Dec 2013