OMIA 001360-93934 : Trimethylaminuria (fishy taint) in Coturnix japonica

In other species: cattle , chicken , mallard

Possibly relevant human trait(s) and/or gene(s) (MIM number): 602079

Mendelian trait/disorder: unknown

Considered a defect: yes

Year key variant first reported: 2013

Molecular basis: Being well aware of the role of mutations in FMO3/FMO6P being causal for this disorder in cattle (OMIA 001360-9913) and chickens (OMIA 001360-9031), Mo et al. (2013) cloned and sequenced the quail FMO3 gene, and identified "a nonsense mutation ([c.992C>T]; Q319X) which was significantly associated with the elevated TMA content in quail egg yolks. Genotype TT at Q319X mutation loci was sensitive to choline. With addition of choline in the feed, the quails with homozygote TT at the Q319X mutation loci laid fish-odour eggs, indicating an interaction between genotype and diet. The results indicated that Q319X mutation was associated with the fishy off-flavor in quail eggs."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
FMO3 Coturnix coturnix - no genomic information (-..-) FMO3 Ensembl

Reference


2013 Mo, F., Zheng, J., Wang, P., Lian, L., Yi, G., Xu, G., Yang, N. :
Quail FMO3 gene cloning, tissue expression profiling, polymorphism detection and association analysis with fishy taint in eggs. PLoS One 8:e81416, 2013. Pubmed reference: 24282592. DOI: 10.1371/journal.pone.0081416.

Edit History


  • Created by Frank Nicholas on 30 Nov 2013
  • Changed by Frank Nicholas on 30 Nov 2013
  • Changed by Frank Nicholas on 01 Dec 2013