OMIA:001404-9986 : Leptin concentration in Oryctolagus cuniculus (rabbit) |
In other species: pig , taurine cattle
Categories: Homeostasis / metabolism phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 164160 (gene) , 614962 (trait) , 601007 (gene) , 614963 (trait)
Mendelian trait/disorder: yes
Disease-related: unknown
Key variant known: no
Species-specific description: Silaeva et al. (2024): "a LEPR knockout rabbit was generated by introducing a deletion of the region around LEPR exon 10 using the CRISPR/Cas9 system. The body weight of the knockout rabbit was significantly higher than the average body weight of the wild type rabbits." This study involves genetically modified/edited organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| LEPR | leptin receptor | Oryctolagus cuniculus | 13 | NC_067386.1 (101028692..100813283) | LEPR | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:001404-9986: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2024 | Silaeva, Y.Y., Safonova, P.D., Popov, D.V., Filatov, M.A., Okulova, Y.D., Shafei, R.A., Skobel, O.I., Vysotskii, D.E., Gubarev, Y.D., Glazko, V.I., Glazko, T.T., Georgiev, P.G., Kosovsky, G.Y., Shepelev, M.V. : |
| Generation of LEPR knockout rabbits with CRISPR/CAS9 System. Dokl Biol Sci 518:248-255, 2024. Pubmed reference: 39212886. DOI: 10.1134/S0012496624600234. |
Edit History
- Created by Imke Tammen2 on 02 Sep 2024
- Changed by Imke Tammen2 on 02 Sep 2024