OMIA:001487-9615 : Myopia in Canis lupus familiaris

In other species: Rhesus monkey

Categories: Vision / eye phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Inheritance: In an investigation of the heritability of lenticular myopia in English Springer Spaniels, Kubai et al. (2013) reported "Moderate heritability was present for refractive error with a mean value of 0.29 (95% highest probability density: 0.07 to 0.50)".

Breeds: English Springer Spaniel, Labrador Retriever.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2013 Kubai, M.A., Labelle, A.L., Hamor, R.E., Mutti, D.O., Famula, T.R., Murphy, C.J. :
Heritability of lenticular myopia in English Springer spaniels. Invest Ophthalmol Vis Sci 54:7324-8, 2013. Pubmed reference: 24071952 . DOI: 10.1167/iovs.12-10993.
2011 Williams, L.A., Kubai, M.A., Murphy, C.J., Mutti, D.O. :
Ocular components in three breeds of dogs with high prevalence of myopia. Optom Vis Sci 88:269-74, 2011. Pubmed reference: 21169876 . DOI: 10.1097/OPX.0b013e3182058ff0.
2008 Black, J., Browning, SR., Collins, AV., Phillips, JR. :
A canine model of inherited myopia: familial aggregation of refractive error in labrador retrievers. Invest Ophthalmol Vis Sci 49:4784-9, 2008. Pubmed reference: 18566472 . DOI: 10.1167/iovs.08-1828.
1999 Mutti, DO., Zadnik, K., Murphy, CJ. :
Naturally occurring vitreous chamber-based myopia in the Labrador retriever. Invest Ophthalmol Vis Sci 40:1577-84, 1999. Pubmed reference: 10359340 .
1992 Murphy, C.J., Zadnik, K., Mannis, M.J. :
Myopia and refractive error in dogs. Invest Ophthalmol Vis Sci 33:2459-63, 1992. Pubmed reference: 1634344 .

Edit History

  • Created by Frank Nicholas on 15 Apr 2010
  • Changed by Frank Nicholas on 29 Sep 2013