Categories: Neoplasm , Haematopoietic system phene

Possible human homologues (MIM numbers): 151410 (gene) , 189980 (gene) , 608232 (trait)

Links to MONDO diseases: No links.

Cross-species summary: Chronic myelogenous leukemia (CML) is a clonal proliferative disorder of a pluripotent stem cell (of myeloid, megakaryocyte, and erythroid and lymphoid lineages) with a specific cytogenetic abnormality. In humans, the disease is most frequently caused by a translocation between chromosomes 22 and 9, resulting in the fusion of the Abelson murine leukemia oncogene (ABL1) with the breakpoint cluster region (BCR). The resulting BCR/ABL fusion gene encodes a tyrosine kinase.

Species in which this phene is found:
dog (Canis lupus familiaris)
pig (Sus scrofa)