OMIA:001513-9615 : Leukaemia, chronic myelogenous in Canis lupus familiaris (dog) |
In other species: pig
Categories: Neoplasm , Haematopoietic system phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 151410 (gene) , 189980 (gene) , 608232 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: no
Mode of inheritance: Somatic mutation
Considered a defect: yes
Key variant known: yes
Year key variant first reported: 2008
Cross-species summary: Chronic myelogenous leukemia (CML) is a clonal proliferative disorder of a pluripotent stem cell (of myeloid, megakaryocyte, and erythroid and lymphoid lineages) with a specific cytogenetic abnormality. In humans, the disease is most frequently caused by a translocation between chromosomes 22 and 9, resulting in the fusion of the Abelson murine leukemia oncogene (ABL1) with the breakpoint cluster region (BCR). The resulting BCR/ABL fusion gene encodes a tyrosine kinase.
Species-specific symbol: CML
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated genes:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| BCR | breakpoint cluster region | Canis lupus familiaris | 26 | NC_051830.1 (29260365..29385328) | BCR | Homologene, Ensembl , NCBI gene |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | Canis lupus familiaris | 9 | NC_051813.1 (54162127..54019016) | ABL1 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2020). OMIA:001513-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2008 | Breen, M., Modiano, JF. : |
| Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans--man and his best friend share more than companionship. Chromosome Res 16:145-54, 2008. Pubmed reference: 18293109. DOI: 10.1007/s10577-007-1212-4. | |
| 2001 | Tarrant, JM., Stokol, T., Blue, JT., McDonough, SP., Farrell, P. : |
| Diagnosis of chronic myelogenous leukemia in a dog using morphologic, cytochemical, and flow cytometric techniques. Vet Clin Pathol 30:19-24, 2001. Pubmed reference: 12024326. | |
| 1983 | Leifer, CE., Matus, RE., Patnaik, AK., MacEwen, EG. : |
| Chronic myelogenous leukemia in the dog. J Am Vet Med Assoc 183:686-9, 1983. Pubmed reference: 6579047. |
Edit History
- Created by Frank Nicholas on 02 Nov 2010
- Changed by Imke Tammen2 on 10 Dec 2020