OMIA 001513-9615 : Chronic myelogenous leukemia in Canis lupus familiaris

In other species: pig

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 151410 (gene) , 189980 (gene) , 608232 (trait)

Mendelian trait/disorder: no

Mode of inheritance: Somatic Mutation

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2008

Cross-species summary: Chronic myelogenous leukemia (CML) is a clonal proliferative disorder of a pluripotent stem cell (of myeloid, megakaryocyte, and erythroid and lymphoid lineages) with a specific cytogenetic abnormality. In humans, the disease is most frequently caused by a translocation between chromosomes 22 and 9, resulting in the fusion of the Abelson murine leukemia oncogene (ABL1) with the breakpoint cluster region (BCR). The resulting BCR/ABL fusion gene encodes a tyrosine kinase.

Species-specific symbol: CML

Associated genes:

Symbol Description Species Chr Location OMIA gene details page Other Links
BCR breakpoint cluster region Canis lupus familiaris 26 NC_051830.1 (29260365..29385328) BCR Homologene, Ensembl, NCBI gene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase Canis lupus familiaris 9 NC_051813.1 (54162127..54019016) ABL1 Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2008 Breen, M., Modiano, JF. :
Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans--man and his best friend share more than companionship. Chromosome Res 16:145-54, 2008. Pubmed reference: 18293109. DOI: 10.1007/s10577-007-1212-4.
2001 Tarrant, JM., Stokol, T., Blue, JT., McDonough, SP., Farrell, P. :
Diagnosis of chronic myelogenous leukemia in a dog using morphologic, cytochemical, and flow cytometric techniques. Vet Clin Pathol 30:19-24, 2001. Pubmed reference: 12024326.
1983 Leifer, CE., Matus, RE., Patnaik, AK., MacEwen, EG. :
Chronic myelogenous leukemia in the dog. J Am Vet Med Assoc 183:686-9, 1983. Pubmed reference: 6579047.

Edit History


  • Created by Frank Nicholas on 02 Nov 2010
  • Changed by Imke Tammen2 on 10 Dec 2020