OMIA:001513-9615 : Chronic myelogenous leukemia in Canis lupus familiaris
In other species: pig
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 151410 (gene) , 189980 (gene) , 608232 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: no
Mode of inheritance: Somatic mutation
Considered a defect: yes
Key variant known: yes
Year key variant first reported: 2008
Cross-species summary: Chronic myelogenous leukemia (CML) is a clonal proliferative disorder of a pluripotent stem cell (of myeloid, megakaryocyte, and erythroid and lymphoid lineages) with a specific cytogenetic abnormality. In humans, the disease is most frequently caused by a translocation between chromosomes 22 and 9, resulting in the fusion of the Abelson murine leukemia oncogene (ABL1) with the breakpoint cluster region (BCR). The resulting BCR/ABL fusion gene encodes a tyrosine kinase.
Species-specific symbol: CML
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|BCR||breakpoint cluster region||Canis lupus familiaris||26||NC_051830.1 (29260365..29385328)||BCR||Homologene, Ensembl , NCBI gene|
|ABL1||ABL proto-oncogene 1, non-receptor tyrosine kinase||Canis lupus familiaris||9||NC_051813.1 (54162127..54019016)||ABL1||Homologene, Ensembl , NCBI gene|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2008||Breen, M., Modiano, JF. :|
|Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans--man and his best friend share more than companionship. Chromosome Res 16:145-54, 2008. Pubmed reference: 18293109 . DOI: 10.1007/s10577-007-1212-4.|
|2001||Tarrant, JM., Stokol, T., Blue, JT., McDonough, SP., Farrell, P. :|
|Diagnosis of chronic myelogenous leukemia in a dog using morphologic, cytochemical, and flow cytometric techniques. Vet Clin Pathol 30:19-24, 2001. Pubmed reference: 12024326 .|
|1983||Leifer, CE., Matus, RE., Patnaik, AK., MacEwen, EG. :|
|Chronic myelogenous leukemia in the dog. J Am Vet Med Assoc 183:686-9, 1983. Pubmed reference: 6579047 .|
- Created by Frank Nicholas on 02 Nov 2010
- Changed by Imke Tammen2 on 10 Dec 2020