OMIA 001534-9031 : Resistance/susceptibility to myxovirus in Gallus gallus
Category: Immune system phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 147150 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal
Considered a defect: unknown
Key variant known: yes
Year key variant first reported: 2002
Species-specific symbol: Mx
Molecular basis: By cloning and sequencing a very likely comparative candidate gene (based on knowledge that the Mx gene product inhibits virus repliaction in other species), Ko et al. (2002) reported that a missense polymorphism at position 631 (Ser to Asn) of the chicken Mx gene confers susceptibility/resistance respectively, to viruses in chickens. The MX gene is now known as MX1.
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|MX1||myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)||Gallus gallus||1||NC_052532.1 (109001609..109022488)||MX1||Homologene, Ensembl, NCBI gene|
By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.
WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
|OMIA Variant ID||Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Source of Genetic Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Inferred EVA rsID||Year Published||PubMed ID(s)||Acknowledgements|
|14||Resistance to myxovirus||MX1||missense||Naturally occurring variant||GRCg6a||1||g.110260061G>A||c.1892G>A||p.(S631N)||rs313590198||2002||11932243||Variant coordinates obtained from or confirmed by EBI's Some Effect Predictor (VEP) tool|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2011||Ewald, S.J., Kapczynski, D.R., Livant, E.J., Suarez, D.L., Ralph, J., McLeod, S., Miller, C. :|
|Association of Mx1 Asn631 variant alleles with reductions in morbidity, early mortality, viral shedding, and cytokine responses in chickens infected with a highly pathogenic avian influenza virus. Immunogenetics 63:363-75, 2011. Pubmed reference: 21286706. DOI: 10.1007/s00251-010-0509-1.|
|2010||Benfield, C.T., Lyall, J.W., Tiley, L.S. :|
|The cytoplasmic location of chicken mx is not the determining factor for its lack of antiviral activity. PLoS One 5:e12151, 2010. Pubmed reference: 20808435. DOI: 10.1371/journal.pone.0012151.|
|O'Neill, A.M., Livant, E.J., Ewald, S.J. :|
|Interferon alpha-induced inhibition of infectious bursal disease virus in chicken embryo fibroblast cultures differing in Mx genotype. Avian Dis 54:802-6, 2010. Pubmed reference: 20608522.|
|Sironi, L., Ramelli, P., Williams, J.L., Mariani, P. :|
|PCR-RFLP genotyping protocol for chicken Mx gene G/A polymorphism associated with the S631N mutation. Genet Mol Res 9:1104-8, 2010. Pubmed reference: 20568055. DOI: 10.4238/vol9-2gmr811.|
|2008||Benfield, C.T., Lyall, J.W., Kochs, G., Tiley, L.S. :|
|Asparagine 631 variants of the chicken Mx protein do not inhibit influenza virus replication in primary chicken embryo fibroblasts or in vitro surrogate assays. J Virol 82:7533-9, 2008. Pubmed reference: 18508886. DOI: 10.1128/JVI.00185-08.|
|Sironi, L., Williams, JL., Moreno-Martin, AM., Ramelli, P., Stella, A., Jianlin, H., Weigend, S., Lombardi, G., Cordioli, P., Mariani, P. :|
|Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631. Virology 380:152-6, 2008. Pubmed reference: 18723201. DOI: 10.1016/j.virol.2008.07.022.|
|2007||Li, XY., Qu, LJ., Hou, ZC., Yao, JF., Xu, GY., Yang, N. :|
|Genomic structure and diversity of the chicken Mx gene. Poult Sci 86:786-9, 2007. Pubmed reference: 17369555.|
|2006||Li, XY., Qu, LJ., Yao, JF., Yang, N. :|
|Skewed allele frequencies of an Mx gene mutation with potential resistance to avian influenza virus in different chicken populations. Poult Sci 85:1327-9, 2006. Pubmed reference: 16830876.|
|Seyama, T., Ko, JH., Ohe, M., Sasaoka, N., Okada, A., Gomi, H., Yoneda, A., Ueda, J., Nishibori, M., Okamoto, S., Maeda, Y., Watanabe, T. :|
|Population research of genetic polymorphism at amino acid position 631 in chicken Mx protein with differential antiviral activity. Biochem Genet 44:437-48, 2006. Pubmed reference: 16955367. DOI: 10.1007/s10528-006-9040-3.|
|2002||Ko, J.H., Jin, H.K., Asano, A., Takada, A., Ninomiya, A., Kida, H., Hokiyama, H., Ohara, M., Tsuzuki, M., Nishibori, M., Mizutani, M., Watanabe, T. :|
|Polymorphisms and the differential antiviral activity of the chicken Mx gene. Genome Res 12:595-601, 2002. Pubmed reference: 11932243. DOI: 10.1101/gr.210702.|
- Created by Frank Nicholas on 12 Nov 2010
- Changed by Frank Nicholas on 10 Oct 2011
- Changed by Frank Nicholas on 09 Dec 2011
- Changed by Frank Nicholas on 21 Sep 2012
- Changed by Frank Nicholas on 16 Apr 2020
- Changed by Frank Nicholas on 15 May 2020