OMIA 001587-9615 : Deficiency of cytosolic arylamine N-acetylation in Canis lupus familiaris |
In other species:
domestic cat
Possibly relevant human trait(s) and/or gene(s) (MIM number):
243400 (trait)
Mendelian trait/disorder:
yes
Mode of inheritance:
Autosomal Recessive
Considered a defect:
unknown
Key variant known:
yes
Year key variant first reported:
1997
Molecular basis:
Trepanier et al. (1997) showed that all dogs, and other canids, lack both NAT1 and NAT2 genes, and hence compleley lack the enzyme cytosolic N-acetyltransferase (NAT).
Genetic testing:
Since all dogs lack the two genes, there is no need for any genetic testing.
Reference
1997 | Trepanier, LA., Ray, K., Winand, NJ., Spielberg, SP., Cribb, AE. : | |
Cytosolic arylamine N-acetyltransferase (NAT) deficiency in the dog and other canids due to an absence of NAT genes. Biochem Pharmacol 54:73-80, 1997. Pubmed reference: 9296352. |
Edit History
- Created by Frank Nicholas on 21 Jul 2011
- Changed by Frank Nicholas on 10 Aug 2011
- Changed by Frank Nicholas on 12 Dec 2011
- Changed by Frank Nicholas on 03 Sep 2012
- Changed by Frank Nicholas on 24 Apr 2019
- Changed by Frank Nicholas on 16 Apr 2020