OMIA 001587-9685 : Deficiency of cytosolic arylamine N-acetylation in Felis catus

In other species: dog

Possibly relevant human trait(s) and/or gene(s) (MIM number): 243400

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: no

Key variant known: yes

Year key variant first reported: 1998

Molecular basis: Trepanier et al. (1998) showed that the relative deficiency of the enzyme cytosolic arylamine N-acetyltransferase (NAT) in felids is due to the presence of only one NAT gene (NAT1), in contrast to the existence of NAT1 and NAT2 genes in other mammals (except in dogs, which lack both NAT1 and NAT2; see OMIA 001587-9615).

Genetic testing: Since all cats lack the NAT2 gene, there is no need for a genetic test.

Reference


1998 Trepanier, LA., Cribb, AE., Spielberg, SP., Ray, K. :
Deficiency of cytosolic arylamine N-acetylation in the domestic cat and wild felids caused by the presence of a single NAT1-like gene. Pharmacogenetics 8:169-79, 1998. Pubmed reference: 10022754.

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  • Created by Frank Nicholas on 21 Jul 2011
  • Changed by Frank Nicholas on 09 Dec 2011
  • Changed by Frank Nicholas on 21 Mar 2012
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  • Changed by Frank Nicholas on 04 Sep 2012
  • Changed by Frank Nicholas on 24 Apr 2019