OMIA:001624-9986 : C6 deficiency in Oryctolagus cuniculus

Categories: Immune system phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 612446 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: yes

Key variant known: no

Cross-species summary: complement component-6 deficiency


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2007 Liu, E., Kitajima, S., Wiese, E., Reifenberg, K., Morimoto, M., Watanabe, T., Fan, J. :
Re-establishment of complement C6-deficient rabbit colony by cryopreserved sperm transported from abroad. Exp Anim 56:167-71, 2007. Pubmed reference: 17460363 .
1998 Schmiedt, W., Kinscherf, R., Deigner, H.P., Kamencic, H., Nauen, O., Kilo, J., Oelert, H., Metz, J., Bhakdi, S. :
Complement C6 deficiency protects against diet-induced atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol 18:1790-5, 1998. Pubmed reference: 9812919 .
1996 Ito, W., Schäfer, H.J., Bhakdi, S., Klask, R., Hansen, S., Schaarschmidt, S., Schofer, J., Hugo, F., Hamdoch, T., Mathey, D. :
Influence of the terminal complement-complex on reperfusion injury, no-reflow and arrhythmias: a comparison between C6-competent and C6-deficient rabbits. Cardiovasc Res 32:294-305, 1996. Pubmed reference: 8796116 .
1992 Giannini, C., Monaco, S., Kirschfink, M., Rother, KO., Lorbacher de Ruiz, H., Nardelli, E., Bonetti, B., Salviati, A., Zanette, GP., Rizzuto, N. :
Inherited neuroaxonal dystrophy in C6 deficient rabbits. J Neuropathol Exp Neurol 51:514-22, 1992. Pubmed reference: 1517772 .
Parra, G., Takekoshi, Y., Striegel, J., Vernier, R.L., Michael, A.F. :
Acute serum sickness in normal and C6 deficient rabbits: role of membrane attack complex. Int J Exp Pathol 73:299-312, 1992. Pubmed reference: 1622842 .
1986 Rother, K. :
Rabbits deficient in C6. Prog Allergy 39:192-201, 1986. Pubmed reference: 3550816 .
1985 Komatsu, M. :
A method for developing hereditary deficiency of complement component in the rabbit Experimental Animals 34:173-182, 1985. Pubmed reference: 4018150 .
Sellei, J. :
C6-deficiency in rabbit serum and its restoration by normal rabbit serum or by normal bovine serum. Vet Immunol Immunopathol 8:27-33, 1985. Pubmed reference: 4038833 .
1982 Abe, T., Komatsu, M., Yamamoto, K., Migita, S. :
[Genetics and some characterization of C6 deficiency in rabbits (author's transl)]. Jikken Dobutsu 31:21-6, 1982. Pubmed reference: 7075684 .
Goldman, M.B., Cohen, C., Stronski, K., Bangalore, S., Goldman, J.N. :
Genetic control of C6 polymorphism and C6 deficiency in rabbits. J Immunol 128:43-8, 1982. Pubmed reference: 6172488 .
1979 Abe, T., Komatsu, M., Oishi, T., Yamamoto, K. :
Development and genetic differences of complement activity in rabbits. Anim Blood Groups Biochem Genet 10:19-26, 1979. Pubmed reference: 507469 .
O'Regan, C.C., Robitaille, P., Pinto-Blonde, M., Chartrand, C. :
Delayed rejection of cardiac xenografts in C6-deficient rabbits. Immunology 38:245-8, 1979. Pubmed reference: 389781 .
1976 Stafford, B.T., Rapaport, S.I., Shen, S.M. :
Effects of endotoxin in cortisone-treated rabbits with a hereditary deficiency of the sixth component of complement (C6 deficiency). Thromb Haemost 35:460-71, 1976. Pubmed reference: 989643 .
1975 Christian, F.A., Gordon, J.L. :
Platelet function in C6-deficient rabbits. Aggregation and secretion induced by collagen and zymosan. Immunology 29:131-41, 1975. Pubmed reference: 1140824 .
Fong, J.S., Good, R.A. :
Congenital and experimentally induced complement deficiency in rabbits. Birth Defects Orig Artic Ser 11:571-6, 1975. Pubmed reference: 125122 .
Lohmann, E., Müller-Berghaus, G. :
Proceedings: Activation of endotoxin-induced intravascular coagulation in congenitally C6-deificient rabbits. Thromb Diath Haemorrh 34:603-4, 1975. Pubmed reference: 1198528 .
1974 Fong, J.S., Rother, K.O., Good, R.A. :
The role of complement in localized shwartzman reaction: studies with congenitally C6-deficient rabbits. Clin Exp Immunol 16:77-88, 1974. Pubmed reference: 4468178 .
Lee, M.J., Lee, M.Y., Dalmasso, A.P., Swaim, W.R. :
Abnormal platelet response to thromboplastin infusion in rabbits deficient in the sixth component of complement. Proc Soc Exp Biol Med 146:732-7, 1974. Pubmed reference: 4841194 .
Müller-Berghaus, G., Lohmann, E. :
The role of complement in endotoxin-induced disseminated intravascular coagulation: studies in congenitally C6-deficient rabbits. Br J Haematol 28:403-18, 1974. Pubmed reference: 4613378 .
1971 Zimmerman, T.S., Arroyove, C.M., Müller-Eberhard, H.J. :
A blood coagulation abnormality in rabbits deficient in the sixth component of complement (C6) and its correction by purified C6. J Exp Med 134:1591-600, 1971. Pubmed reference: 5126641 .
1966 Rother, K., Rother, U., Müller-Eberhard, H.J., Nilsson, J.R. :
Deficiency of the sixth component of complement in rabbits with an inherited complement defect. J Exp Med 124:773-85, 1966. Pubmed reference: 5922290 .

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  • Created by Frank Nicholas on 11 Oct 2011
  • Changed by Frank Nicholas on 11 Oct 2011