OMIA:001667-9913 : Heat tolerance in Bos taurus (taurine cattle)

In other species: chicken , dog , pig , banteng , indicine cattle (zebu) , goat , sheep , Japanese disc abalone

Categories: Homeostasis / metabolism phene

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: no

Key variant known: no

Species-specific description: This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - in addition to the occurrence of natural variants, variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001667-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 De Campos, J.S., Onasanya, G.O., Ubong, A., T Yusuff, A., Adenaike, A.S., Mohammed, A.A., Ikeobi, C.O. :
Potentials of single nucleotide polymorphisms and genetic diversity studies at HSP90AB1 gene in Nigerian White Fulani, Muturu, and N'Dama cattle breeds. Trop Anim Health Prod 56:58, 2024. Pubmed reference: 38267723. DOI: 10.1007/s11250-024-03909-z.
Dutta, G., Alex, R., Singh, A., Gowane, G.R., Vohra, V., De, S., Verma, A., Ludri, A. :
Functional transcriptome analysis revealed upregulation of MAPK-SMAD signalling pathways in chronic heat stress in crossbred cattle. Int J Biometeorol , 2024. Pubmed reference: 38720050. DOI: 10.1007/s00484-024-02672-y.
Hernandez, A.S., Zayas, G.A., Rodriguez, E.E., Sarlo Davila, K.M., Rafiq, F., Nunez, A.N., Titto, C.G., Mateescu, R.G. :
Exploring the genetic control of sweat gland characteristics in beef cattle for enhanced heat tolerance. J Anim Sci Biotechnol 15:66, 2024. Pubmed reference: 38715151. DOI: 10.1186/s40104-024-01025-4.
Hu, L., Fang, H., Abbas, Z., Luo, H., Brito, L.F., Wang, Y., Xu, Q. :
The HSP90AA1 gene is involved in heat stress responses and its functional genetic polymorphism are associated with heat tolerance in Holstein cows. J Dairy Sci 107:5132-5149, 2024. Pubmed reference: 38395401. DOI: 10.3168/jds.2023-24007.
Laporta, J., Khatib, H., Zachut, M. :
Review: Phenotypic and molecular evidence of inter- and trans-generational effects of heat stress in livestock mammals and humans. Animal :101121, 2024. Pubmed reference: 38531705. DOI: 10.1016/j.animal.2024.101121.
Lazzari, J., Isola, J.V.V., Szambelan, V.L., Menegazzi, G., Busanello, M., Rovani, M.T., Sarubbi, J., Schmitt, E., Ferreira, R., Gonçalves, P.B.D., Gasperin, B.G., Mondadori, R.G. :
Thermoregulatory response of black or red lactating Holstein cows in the hot and cold season in southern Brazil. J Therm Biol 121:S0306-4565(24)00051-2:103833, 2024. Pubmed reference: 38527387. DOI: 10.1016/j.jtherbio.2024.103833.
Lee, Y.J., Lee, J.W., Huang, C.W., Yang, K.T., Peng, S.Y., Yu, C., Lee, Y.H., Lai, I.L., Shen, P.C. :
Identification of molecular profile of ear fibroblasts derived from spindle-transferred Holstein cattle with ooplasts from Taiwan Yellow cattle under heat stress. Animals (Basel) 14:1371, 2024. Pubmed reference: 38731375. DOI: 10.3390/ani14091371.
Liu, D., Yang, Y., Chen, Z., Fan, Y., Liu, J., Xu, Y., Ahmed, Z., Zhang, J., Li, F., Qi, X., Song, W., Zhu, K., Gongque, J., Li, G., Huang, B., Lei, C. :
Temperature adaptation patterns in Chinese cattle revealed by TRPM2 gene mutation analysis. Anim Biotechnol 35:2299944, 2024. Pubmed reference: 38164963. DOI: 10.1080/10495398.2023.2299944.
Luna-Azuara, C.G., Montaño-Bermúdez, M., Calderón-Chagoya, R., Ríos-Utrera, Á., Martínez-Velázquez, G., Vega-Murillo, V.E. :
Genetic diversity of SNPs associated with candidate genes for heat stress in Coreño Creole cattle in Mexico. Trop Anim Health Prod 56:71, 2024. Pubmed reference: 38326660. DOI: 10.1007/s11250-024-03917-z.
Oloo, R.D., Ekine-Dzivenu, C.C., Mrode, R., Bennewitz, J., Ojango, J.M.K., Kipkosgei, G., Gebreyohanes, G., Okeyo, A.M., Chagunda, M.G.G. :
Genetic analysis of phenotypic indicators for heat tolerance in crossbred dairy cattle. Animal 18:S1751-7311(24)00070-3:101139, 2024. Pubmed reference: 38626705. DOI: 10.1016/j.animal.2024.101139.
Wang, L., Yan, X., Wu, H., Wang, F., Zhong, Z., Zheng, G., Xiao, Q., Wu, K., Na, W. :
Selection signal analysis reveals Hainan Yellow cattle are being selectively bred for heat tolerance. Animals (Basel) 14:775, 2024. Pubmed reference: 38473160. DOI: 10.3390/ani14050775.
2023 Cartwright, S.L., Schmied, J., Karrow, N., Mallard, B.A. :
Impact of heat stress on dairy cattle and selection strategies for thermotolerance: a review. Front Vet Sci 10:1198697, 2023. Pubmed reference: 37408833. DOI: 10.3389/fvets.2023.1198697.
Freitas, P.H.F., Johnson, J.S., Wen, H., Maskal, J.M., Tiezzi, F., Maltecca, C., Huang, Y., DeDecker, A.E., Schinckel, A.P., Brito, L.F. :
Genetic parameters for automatically-measured vaginal temperature, respiration efficiency, and other thermotolerance indicators measured on lactating sows under heat stress conditions. Genet Sel Evol 55:65, 2023. Pubmed reference: 37730542. DOI: 10.1186/s12711-023-00842-x.
Giannone, C., Bovo, M., Ceccarelli, M., Torreggiani, D., Tassinari, P. :
Review of the heat stress-induced responses in dairy cattle. Animals (Basel) 13:3451, 2023. Pubmed reference: 38003069. DOI: 10.3390/ani13223451.
Gujar, G., Tiwari, M., Yadav, N., Monika, D. :
Heat stress adaptation in cows - Physiological responses and underlying molecular mechanisms. J Therm Biol 118:103740, 2023. Pubmed reference: 37976864. DOI: 10.1016/j.jtherbio.2023.103740.
Habimana, V., Nguluma, A.S., Nziku, Z.C., Ekine-Dzivenu, C.C., Morota, G., Mrode, R., Chenyambuga, S.W. :
Heat stress effects on milk yield traits and metabolites and mitigation strategies for dairy cattle breeds reared in tropical and sub-tropical countries. Front Vet Sci 10:1121499, 2023. Pubmed reference: 37483284. DOI: 10.3389/fvets.2023.1121499.
Habimana, V., Ekine-Dzivenu, C.C., Nguluma, A.S., Nziku, Z.C., Morota, G., Chenyambuga, S.W., Mrode, R. :
Genes and models for estimating genetic parameters for heat tolerance in dairy cattle. Front Genet 14:1127175, 2023. Pubmed reference: 36923799. DOI: 10.3389/fgene.2023.1127175.
Kambal, S., Tijjani, A., Ibrahim, S.A.E., Ahmed, M.A., Mwacharo, J.M., Hanotte, O. :
Candidate signatures of positive selection for environmental adaptation in indigenous African cattle: A review. Anim Genet 54:689-708, 2023. Pubmed reference: 37697736. DOI: 10.1111/age.13353.
Lemal, P., May, K., König, S., Schroyen, M., Gengler, N. :
Invited review: From heat stress to disease-Immune response and candidate genes involved in cattle thermotolerance. J Dairy Sci 106:4471-4488, 2023. Pubmed reference: 37164864. DOI: 10.3168/jds.2022-22727.
Lyu, Y., Guan, X., Xu, X., Wang, P., Li, Q., Panigrahi, M., Zhang, J., Chen, N., Huang, B., Lei, C. :
A whole genome scan reveals distinct features of selection in Zhaotong cattle of Yunnan province. Anim Genet 54:731-742, 2023. Pubmed reference: 37796667. DOI: 10.1111/age.13363.
Mateescu, R.G., Sarlo Davila, K.M., Hernandez, A.S., Andrade, A.N., Zayas, G.A., Rodriguez, E.E., Dikmen, S., Oltenacu, P.A. :
Impact of Brahman genetics on skin histology characteristics with implications for heat tolerance in cattle. Front Genet 14:1107468, 2023. Pubmed reference: 37229201. DOI: 10.3389/fgene.2023.1107468.
Osei-Amponsah, R., Dunshea, F.R., Leury, B.J., Abhijith, A., Chauhan, S.S. :
Association of phenotypic markers of heat tolerance with Australian genomic estimated breeding values and dairy cattle selection indices. Animals (Basel) 13:2259, 2023. Pubmed reference: 37508037. DOI: 10.3390/ani13142259.
Rockett, P.L., Campos, I.L., Baes, C.F., Tulpan, D., Miglior, F., Schenkel, F.S. :
Genetic evaluation of heat tolerance in Holsteins using test-day production records and NASA POWER weather data. J Dairy Sci 106:6995-7007, 2023. Pubmed reference: 37562648. DOI: 10.3168/jds.2022-22776.
Shandilya, U.K., Sharma, A., Sodhi, M., Mukesh, M. :
Editing of HSF-1 and Na/K-ATPase α1 subunit by CRISPR/Cas9 reduces thermal tolerance of bovine skin fibroblasts to heat shock in vitro. Anim Biotechnol 34:3626-3636, 2023. Pubmed reference: 36905150. DOI: 10.1080/10495398.2023.2187403.
Shephard, R.W., Maloney, S.K. :
A review of thermal stress in cattle. Aust Vet J 101:417-429, 2023. Pubmed reference: 37620993. DOI: 10.1111/avj.13275.
Worku, D., Hussen, J., De Matteis, G., Schusser, B., Alhussien, M.N. :
Candidate genes associated with heat stress and breeding strategies to relieve its effects in dairy cattle: a deeper insight into the genetic architecture and immune response to heat stress. Front Vet Sci 10:1151241, 2023. Pubmed reference: 37771947. DOI: 10.3389/fvets.2023.1151241.
2019 Rong, Y., Zeng, M., Guan, X., Qu, K., Liu, J., Zhang, J., Chen, H., Huang, B., Lei, C. :
Association of HSF1 genetic variation with heat tolerance in Chinese cattle. Animals (Basel) 9:1027, 2019. Pubmed reference: 31775331. DOI: 10.3390/ani9121027.
2016 Santana, M.L., Bignardi, A.B., Pereira, R.J., Stefani, G., El Faro, L. :
Genetics of heat tolerance for milk yield and quality in Holsteins. Animal 11:4-14, 2016. Pubmed reference: 27532229. DOI: 10.1017/S1751731116001725.

Edit History

  • Created by Frank Nicholas on 30 Aug 2016
  • Changed by Imke Tammen2 on 31 Mar 2023
  • Changed by Imke Tammen2 on 18 Dec 2023