OMIA:001667-9615 : Heat tolerance in Canis lupus familiaris

In other species: chicken , pig , cattle , zebu , goat , Japanese disc abalone

Categories: Homeostasis / metabolism phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: no

Mapping: Huson et al. (2012) conducted two GWAS analyses for heat tolerance in Alaskan Sprint Racing Sled dogs; on 150 dogs genotyped with the Illumina HD Canine SNP chip (yielding 115,425 SNPs for analysis), and on 45 dogs genotyped with the Affymetrix v2.0 Canine SNP chip (yielding 48,716 SNPs for analysis). The results highlighted a region on chromosome CFA10, which includes the MYH9 gene, which was regarded as the most likely candidate.


2012 Huson, H.J., vonHoldt, B.M., Rimbault, M., Byers, A.M., Runstadler, J.A., Parker, H.G., Ostrander, E.A. :
Breed-specific ancestry studies and genome-wide association analysis highlight an association between the MYH9 gene and heat tolerance in Alaskan sprint racing sled dogs. Mamm Genome 23:178-94, 2012. Pubmed reference: 22105876 . DOI: 10.1007/s00335-011-9374-y.

Edit History

  • Created by Frank Nicholas on 27 Nov 2011
  • Changed by Frank Nicholas on 20 May 2013