OMIA:001691-9615 : Recombination rate in Canis lupus familiaris
In other species: Mallard , chicken , domestic cat , horse , pig , taurine cattle , goat , sheep
Categories: Normal phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 612042 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: no
Molecular basis: Axelsson et al. (2012) provided evidence that the canine lineage has lost the gene PRDM9, which in other lineages plays a central role in initiating recombination, creating recombination "hotspots". Lacking this gene, the canine lineage has a "greater evolutionary stability of recombination hotspots".
Campbell et al. (2016) concluded that despite lacking PRDM9, "dogs have similar broad scale properties of recombination to humans, while fine-scale recombination is similar to other species lacking PRDM9."
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2016||Campbell, C.L., Bhérer, C., Morrow, B.E., Boyko, A.R., Auton, A. :|
|A Pedigree-Based Map of Recombination in the Domestic Dog Genome. G3 (Bethesda) :, 2016. Pubmed reference: 27591755 . DOI: 10.1534/g3.116.034678.|
|2013||Auton, A., Rui Li, Y., Kidd, J., Oliveira, K., Nadel, J., Holloway, J.K., Hayward, J.J., Cohen, P.E., Greally, J.M., Wang, J., Bustamante, C.D., Boyko, A.R. :|
|Genetic Recombination Is Targeted towards Gene Promoter Regions in Dogs. PLoS Genet 9:e1003984, 2013. Pubmed reference: 24348265 . DOI: 10.1371/journal.pgen.1003984.|
|2012||Axelsson, E., Webster, M.T., Ratnakumar, A. :|
|Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome. Genome Res 22:51-63, 2012. Pubmed reference: 22006216 . DOI: 10.1101/gr.124123.111.|
- Created by Frank Nicholas on 08 Jun 2012
- Changed by Frank Nicholas on 05 Aug 2013
- Changed by Frank Nicholas on 04 Sep 2016