OMIA:001694-9685 : Resistance/susceptibility to lentivirus in Felis catus (domestic cat) |
In other species: chimpanzee , sheep
Categories: Immune system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 186940 (gene) , 607750 (gene)
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal dominant
Disease-related: yes
Key variant known: yes
Year key variant first reported: 2016
Species-specific name: Resistance/susceptibility to feline immunodeficiency virus (FIV)
Molecular basis: Yoshikawa et al. (2016) "demonstrated that feline A3Z3 hap V is maintained under conditions of positive selection and is resistant to FIV Vif-dependent degradation. . . . To the best of our knowledge, this is the first report providing evidence of the evolutionary arms race between domestic cat and its lentivirus FIV". The likely causal variant for resistance is 65I.
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| APOBEC3C | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C | Felis catus | B4 | NC_058374.1 (132502418..132508873) | APOBEC3C | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001694-9685: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2016 | Yoshikawa, R., Izumi, T., Yamada, E., Nakano, Y., Misawa, N., Ren, F., Carpenter, M.A., Ikeda, T., Münk, C., Harris, R.S., Miyazawa, T., Koyanagi, Y., Sato, K. : |
| A naturally occurring domestic cat APOBEC3 variant confers resistance to feline immunodeficiency virus infection. J Virol 90:474-85, 2016. Pubmed reference: 26491161. DOI: 10.1128/JVI.02612-15. |
Edit History
- Created by Frank Nicholas on 04 Jun 2016
- Changed by Frank Nicholas on 04 Jun 2016
- Changed by Frank Nicholas on 15 May 2020
- Changed by Imke Tammen2 on 16 Oct 2023