OMIA 001726-9823 : Resistance to Salmonella enterica serovar Choleraesuis (SC) in Sus scrofa

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: no

Molecular basis: Shinkai et al. (2011) reported results of in vitro studies showing that three missense SNPs in porcine toll-like receptors ("TLR5(R148L), TLR5(P402L), and TLR2(V703M) attenuated the responses to SC by the cells transfected with the TLR genes", providing circumstantial evidence for inherited resistance to SC. Muneta et al. (2012) developed a genotyping test for the second of these SNPs "(TLR5) (C1205T; P402L)", which will enable investigation of the effect of this SNP on resistance.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2012 Muneta, Y., Minagawa, Y., Kusumoto, M., Shinkai, H., Uenishi, H., Splichal, I. :
Allele-specific primer polymerase chain reaction for a single nucleotide polymorphism (C1205T) of swine toll-like receptor 5 and comparison of the allelic frequency among several pig breeds in Japan and the Czech Republic. Microbiol Immunol 56:385-91, 2012. Pubmed reference: 22420886. DOI: 10.1111/j.1348-0421.2012.00450.x.
2011 Shinkai, H., Suzuki, R., Akiba, M., Okumura, N., Uenishi, H. :
Porcine Toll-like receptors: recognition of Salmonella enterica serovar Choleraesuis and influence of polymorphisms. Mol Immunol 48:1114-20, 2011. Pubmed reference: 21388684. DOI: 10.1016/j.molimm.2011.02.004.

Edit History


  • Created by Frank Nicholas on 21 Oct 2012
  • Changed by Frank Nicholas on 24 Nov 2012