OMIA 001726-9823 : Resistance to Salmonella enterica serovar Choleraesuis (SC) in Sus scrofa

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: no

Markers: Shinkai et al. (2011) reported results of in vitro studies showing that three missense SNPs in porcine toll-like receptors ("TLR5(R148L), TLR5(P402L), and TLR2(V703M) attenuated the responses to SC by the cells transfected with the TLR genes", providing circumstantial evidence for inherited resistance to SC. Muneta et al. (2012) developed a genotyping test for the second of these SNPs "(TLR5) (C1205T; P402L)", which will enable investigation of the effect of this SNP on resistance.

Miguel and Mingala (2019) reported the frequency of "resistant" and susceptible" alleles at the BPI locus in a range of pig breeds, but provided no data on resistance or susceptibility in the genotyped pigs. The original report that described these alleles (Tuggle et al., 2004) actually shows that genetic variation at this locus is one of an unknown number of factors contributing to variation in resistance to Salmonella infection. It can be concluded that the search is still on for useful markers for resistance to Salmonella infection.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2019 Miguel, M.A., Mingala, C.N. :
Screening of Pig (Sus scrofa) Bactericidal Permeability-Increasing Protein (BPI) Gene as Marker for Disease Resistance. Anim Biotechnol 30:146-150, 2019. Pubmed reference: 29580199. DOI: 10.1080/10495398.2018.1450266.
2012 Muneta, Y., Minagawa, Y., Kusumoto, M., Shinkai, H., Uenishi, H., Splichal, I. :
Allele-specific primer polymerase chain reaction for a single nucleotide polymorphism (C1205T) of swine toll-like receptor 5 and comparison of the allelic frequency among several pig breeds in Japan and the Czech Republic. Microbiol Immunol 56:385-91, 2012. Pubmed reference: 22420886. DOI: 10.1111/j.1348-0421.2012.00450.x.
2011 Shinkai, H., Suzuki, R., Akiba, M., Okumura, N., Uenishi, H. :
Porcine Toll-like receptors: recognition of Salmonella enterica serovar Choleraesuis and influence of polymorphisms. Mol Immunol 48:1114-20, 2011. Pubmed reference: 21388684. DOI: 10.1016/j.molimm.2011.02.004.
2004 Tuggle, C.K., Shi, X., Marklund, L., Stumbaugh, A., Stabel, T.J., Mellencamp, M.A., Galina-Pantoja, L., Bastiaansen, J. :
Association of bacterial infection traits with genetic variation at candidate genes for porcine disease resistance. Animal Industry Report. AS 650. ASL R1952; Iowa State University :, 2004.

Edit History


  • Created by Frank Nicholas on 21 Oct 2012
  • Changed by Frank Nicholas on 24 Nov 2012
  • Changed by Frank Nicholas on 12 Sep 2019