Categories: Renal / urinary system phene

Possible human homologues (MIM numbers): 603592 (trait) , 613274 (gene)

Links to relevant human diseases in MONDO:

• MONDO:0011346: xanthinuria type II

Cross-species summary: Animals with hereditary xanthinuria (excretion of large amounts of xanthine in the urine) may be asymptomatic, may have subclinical uroliths (xanthine stones), or present with clinical signs of urolithiasis. Urolith formation can be influenced by other biologic and environmental factors such as sex, diet and urine properties. Xanthinuria, type I (OMIA:002445) is caused by variation in the XDH gene and xanthinuria, type II (OMIA:001819) is caused by variation in the MOCOS gene. Information relating to xanthinuria without identified causal variants is listed under xanthinuria, generic (OMIA:001283).

Species in which this phene is found:
dog (Canis lupus familiaris)
taurine cattle (Bos taurus)