OMIA:001819-9615 : Xanthinuria, type II in Canis lupus familiaris (dog)
In other species: taurine cattle
Categories: Renal / urinary system phene
Links to MONDO diseases:
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal recessive
Considered a defect: yes
Key variant known: yes
Year key variant first reported: 2021
Cross-species summary: Animals with hereditary xanthinuria (excretion of large amounts of xanthine in the urine) may be asymptomatic, may have subclinical uroliths (xanthine stones), or present with clinical signs of urolithiasis. Urolith formation can be influenced by other biologic and environmental factors such as sex, diet and urine properties. Xanthinuria, type I (OMIA002445) is caused by variation in the XDH gene and xanthinuria, type II (OMIA 001819) is caused by variation in the MOCOS gene. Information relating to xanthinuria without identified causal variants is listed under xanthinuria, generic (OMIA 001283).
Species-specific name: Xanthine urolithiasis; xanthine nephrolithiasis
Inheritance: Tate et al. (2021) conducted pedigree analysis in Manchester Terriers and their findings were consistent with autosomal recessive inheritance.
Molecular basis: Furrow et al. (2016) reported in a conference abstract the identification of three likely disease-causing mutations for xanthine urolithiasis. Affected Cavalier King Charles Spaniels had a mutation resulting in a premature stop codon in the molybdenum cofactor sulfurase gene (MOCOS), affected Toy Manchester Terriers had a splice site mutation in MOCOS, and an affected mixed breed dog had a splice site mutation in the xanthine dehydrogenase (XDH) gene. These findings were included in the publication by Tate et al. (2021).
Tate et al. (2021): "The aim of this study was to uncover variants underlying risk for xanthinuria in dogs. Affected dogs included two Manchester Terriers, three Cavalier King Charles Spaniels, an English Cocker Spaniel, a Dachshund, and a mixed-breed dog. ...Sanger sequencing of [candidate genes] XDH and MOCOS identified four putative causal variants ... : an XDH c.654G > A splice site variant that results in skipping of exon 8 (mixed-breed dog), a MOCOS c.232G > T splice site variant that results in skipping of exon 2 (Manchester Terriers), a MOCOS p.Leu46Pro missense variant (Dachshund), and a MOCOS p.Ala128Glyfs*30 frameshift variant that results in a premature stop codon (Cavalier King Charles Spaniels and English Cocker Spaniel). ... All variants were found in a homozygous state in the affected dogs, consistent with an autosomal recessive mode of inheritance."
Have human generated variants been created, e.g. through genetic engineering and gene editing
Clinical features: In affected dogs with MOCOS deficiency excess xanthine builds up in the urine, a product which has a low solubility and readily precipitates out of urine, creating xanthine calculi (Furrow et al., 2016). These calculi act similar to most uroliths, creating partial or complete urethral obstruction, resulting in intermittent or consistent stranguria and dysuria, and may result in secondary renal damage (Furrow et al., 2016). In the dogs investigated by Tate et al. (2021) "age at first diagnosis ranged from 7 weeks to 4 years."
IT thanks DVM student Cameron Stuart, who provided the basis of this contribution in May 2023.
Prevalence: The allele frequency of the MOCOS c.232G > T (p.Gly78Cys) variant was 0,13 and 0,10 in 386 Manchester Terriers and 285 English Toy Terriers, respectively. The allele frequency of the MOCOS c.383delC variant was 0.03 and 0 in 109 Cavalier King Charles Spaniels and 42 English Cocker Spaniels, respectively. The MOCOS c.137 T > C variant was absent from a population of 116 Dachshunds. (Tate et al., 2021)
Cavalier King Charles Spaniel,
English Cocker Spaniel,
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|MOCOS||molybdenum cofactor sulfurase||Canis lupus familiaris||7||NC_051811.1 (53971999..53918314)||MOCOS||Homologene, Ensembl , NCBI gene|
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
|OMIA Variant ID||Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Source of Genetic Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Inferred EVA rsID||Year Published||PubMed ID(s)||Acknowledgements|
|1356||Cavalier King Charles Spaniel English Cocker Spaniel||Xanthinuria, type II||MOCOS||deletion, small (<=20)||Naturally occurring variant||CanFam3.1||7||g.53989863del||c.383del||p.(A128Gfs*30)||c.383delC; transcript ENSCAFT00000028243.4; genomic position based on supplementary table S3 (Tate et al., 2021)||2021||34584846|
|1355||Manchester Terrier||Xanthinuria, type II||MOCOS||splicing||Naturally occurring variant||CanFam3.1||7||g.53995018C>A||c.232G>T||p.(G48_Y77del)||ENSCAFT00000028243.4; “Ensembl VEP determined the consequence of the variant to be a missense, splice region variant … the variant results in the removal of all 90 bp (30 amino acids) of exon 2 (p.Gly48_Tyr77del); the genomic position is based on supplementary table S3 (Tate et al., 2021)”; transcript ENSCAFT00000028243.4||2021||34584846|
|1357||Dachshund||Xanthinuria, type II||MOCOS||missense||Naturally occurring variant||CanFam3.1||7||g.54001790A>G||c.137T>C||p.(L46P)||transcript ENSCAFT00000028243.4; genomic position based on supplementary table S3 (Tate et al., 2021)||2021||34584846|
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Tate, N.M., Minor, K.M., Lulich, J.P., Mickelson, J.R., Berent, A., Foster, J.D., Petersen, K.H., Furrow, E. :|
|Multiple variants in XDH and MOCOS underlie xanthine urolithiasis in dogs. Mol Genet Metab Rep 29:100792, 2021. Pubmed reference: 34584846. DOI: 10.1016/j.ymgmr.2021.100792.|
|2016||Furrow, E., Tate, N., Minor, K., Mickelson, J., Peterson, K., Lulich, J. :|
|2016 ACVIM Forum Research Report Program: Three diverse mutations underlying canine xanthine urolithiasis. J Vet Intern Med 30:1537, 2016. DOI: 10.1111/jvim.13963.|
|2013||Jacinto, A.M., Mellanby, R.J., Chandler, M., Bommer, N.X., Carruthers, H., Fairbanks, L.D., Gow, A.G. :|
|Urine concentrations of xanthine, hypoxanthine and uric acid in UK Cavalier King Charles spaniels. J Small Anim Pract 54:395-8, 2013. Pubmed reference: 23859747. DOI: 10.1111/jsap.12106.|
|2011||Gow, A.G., Fairbanks, L.D., Simpson, J.W., Jacinto, A.M., Ridyard, A.E. :|
|Xanthine urolithiasis in a Cavalier King Charles spaniel. Vet Rec 169:209, 2011. Pubmed reference: 21742684. DOI: 10.1136/vr.d3932.|
|1998||Flegel, T., Freistadt, R., Haider, W. :|
|Xanthine urolithiasis in a dachshund Veterinary Record 143:420-423, 1998. Pubmed reference: 9807792.|
|1997||Kucera, J., Bulkova, T., Rychla, R., Jahn, P. :|
|Bilateral xanthine nephrolithiasis in a dog Journal of Small Animal Practice 38:302-305, 1997. Pubmed reference: 9239633.|
|Vanzuilen, C.D., Nickel, R.F., Vandijk, T.H., Reijngoud, D.J. :|
|Xanthinuria in a family of Cavalier King Charles spaniels Veterinary Quarterly 19:172-174, 1997. Pubmed reference: 9413115.|
|1996||van Zuilen, C.D., Nickel, R.F., van Dijk, T.H., Reijngoud, D.J. :|
|Xanthinuria (xanthine oxidase deficiency) in two Cavalier King Charles spaniels Veterinary Quarterly 18:S 24-S 25, 1996.|
|1969||Delbarre, F., Holtzer, A., Auscher, C. :|
|[Xanthine urinary lithiasis and xanthinuria in a dachshund. Deficiency, probably genetic, of the xanthine oxidase system]. C R Acad Hebd Seances Acad Sci D 269:1449-52, 1969. Pubmed reference: 4982510.|
- Created by Imke Tammen2 on 03 Oct 2021
- Changed by Imke Tammen2 on 03 Oct 2021
- Changed by Imke Tammen2 on 09 Jun 2023