OMIA:001856-9913 : Tuberculosis, susceptibility/resistance to in Bos taurus

In other species: pig , indicine cattle (zebu) , African buffalo , water buffalo

Categories: Immune system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 607949 (trait) , 611046 (trait) , 612929 (trait) , 300259 (trait) , 607948 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Species-specific description: This phene includes references to studies involving genetically modified organisms (GMO).

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:001856-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Banos, G. :
Selective breeding can contribute to bovine tuberculosis control and eradication. Ir Vet J 76:19, 2023. Pubmed reference: 37620894 . DOI: 10.1186/s13620-023-00250-z.
Blowey, R. :
A look at bovine TB control over 70 years. Vet Rec 192:380, 2023. Pubmed reference: 37288928 . DOI: 10.1002/vetr.3030.
Maurić Maljković, M., Vlahek, I., Piplica, A., Ekert Kabalin, A., Sušić, V., Stevanović, V. :
Prospects of toll-like receptors in dairy cattle breeding. Anim Genet :, 2023. Pubmed reference: 37051618 . DOI: 10.1111/age.13325.
Voller, C., Brouwer, A., Upton, P.A., Waller, E., Duncan, D., Harris, K.A., Marriott, E., Avigad, R. :
Bovine TB infection status in cattle in Great Britain in 2021. Vet Rec 193:e3288, 2023. Pubmed reference: 37477314 . DOI: 10.1002/vetr.3288.
2021 Chai, J., Wang, Q., Qin, B., Wang, S., Wang, Y., Shahid, M., Liu, K., Zhang, Y., Qu, W. :
Association of NOS2A gene polymorphisms with susceptibility to bovine tuberculosis in Chinese Holstein cattle. PLoS One 16:e0253339, 2021. Pubmed reference: 34138949 . DOI: 10.1371/journal.pone.0253339.
Singh, P., Ali, S.A. :
Impact of CRISPR-Cas9-based genome engineering in farm animals. Vet Sci 8:122, 2021. Pubmed reference: 34209174 . DOI: 10.3390/vetsci8070122.
2020 Callaby, R., Kelly, R., Mazeri, S., Egbe, F., Benedictus, L., Clark, E., Doeschl-Wilson, A., Bronsvoort, B., Salavati, M., Muwonge, A. :
Genetic Diversity of Cameroon Cattle and a Putative Genomic Map for Resistance to Bovine Tuberculosis. Front Genet 11:550215, 2020. Pubmed reference: 33281865 . DOI: 10.3389/fgene.2020.550215.
Holder, A., Garty, R., Elder, C., Mesnard, P., Laquerbe, C., Bartens, M.C., Salavati, M., Shabbir, M.Z., Tzelos, T., Connelly, T., Villarreal-Ramos, B., Werling, D. :
Analysis of genetic variation in the bovine SLC11A1 gene, its influence on the expression of NRAMP1 and potential association with resistance to bovine tuberculosis. Front Microbiol 11:1420, 2020. Pubmed reference: 32714308 . DOI: 10.3389/fmicb.2020.01420.
2019 González-Ruiz, S., Strillacci, M.G., Durán-Aguilar, M., Cantó-Alarcón, G.J., Herrera-Rodríguez, S.E., Bagnato, A., Guzmán, L.F., Milián-Suazo, F., Román-Ponce, S.I. :
Genome-wide association study in Mexican Holstein cattle reveals novel quantitative trait loci regions and confirms mapped loci for resistance to bovine tuberculosis. Animals (Basel) 9:, 2019. Pubmed reference: 31480266 . DOI: 10.3390/ani9090636.
Ring, S.C., Purfield, D.C., Good, M., Breslin, P., Ryan, E., Blom, A., Evans, R.D., Doherty, M.L., Bradley, D.G., Berry, D.P. :
Variance components for bovine tuberculosis infection and multi-breed genome-wide association analysis using imputed whole genome sequence data. PLoS One 14:e0212067, 2019. Pubmed reference: 30763354 . DOI: 10.1371/journal.pone.0212067.
2017 Gao, Y., Wu, H., Wang, Y., Liu, X., Chen, L., Li, Q., Cui, C., Liu, X., Zhang, J., Zhang, Y. :
Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects. Genome Biol 18:13, 2017. Pubmed reference: 28143571 . DOI: 10.1186/s13059-016-1144-4.
Liu, K., Zhang, B., Teng, Z., Wang, Y., Dong, G., Xu, C., Qin, B., Song, C., Chai, J., Li, Y., Shi, X., Shu, X., Zhang, Y. :
Association between SLC11A1 (NRAMP1) polymorphisms and susceptibility to tuberculosis in Chinese Holstein cattle. Tuberculosis (Edinb) 103:10-15, 2017. Pubmed reference: 28237028 . DOI: 10.1016/
2016 Broughan, J.M., Judge, J., Ely, E., Delahay, R.J., Wilson, G., Clifton-Hadley, R.S., Goodchild, A.V., Bishop, H., Parry, J.E., Downs, S.H. :
A review of risk factors for bovine tuberculosis infection in cattle in the UK and Ireland. Epidemiol Infect :1-28, 2016. Pubmed reference: 27452974 . DOI: 10.1017/S095026881600131X.
2015 Wu, H., Wang, Y., Zhang, Y., Yang, M., Lv, J., Liu, J., Zhang, Y. :
TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis. Proc Natl Acad Sci U S A 112:E1530-9, 2015. Pubmed reference: 25733846 . DOI: 10.1073/pnas.1421587112.
2014 Bermingham, M.L., Bishop, S.C., Woolliams, J.A., Pong-Wong, R., Allen, A.R., McBride, S.H., Ryder, J.J., Wright, D.M., Skuce, R.A., McDowell, S.W., Glass, E.J. :
Genome-wide association study identifies novel loci associated with resistance to bovine tuberculosis. Heredity (Edinb) :, 2014. Pubmed reference: 24496092 . DOI: 10.1038/hdy.2013.137.
2013 Amos, W., Brooks-Pollock, E., Blackwell, R., Driscoll, E., Nelson-Flower, M., Conlan, A.J. :
Genetic predisposition to pass the standard SICCT test for bovine tuberculosis in British cattle. PLoS One 8:e58245, 2013. Pubmed reference: 23554880 . DOI: 10.1371/journal.pone.0058245.
le Roex, N., van Helden, P.D., Koets, A.P., Hoal, E.G. :
Bovine TB in livestock and wildlife: what's in the genes? Physiol Genomics 45:631-7, 2013. Pubmed reference: 23757394 . DOI: 10.1152/physiolgenomics.00061.2013.
2012 Finlay, E.K., Berry, D.P., Wickham, B., Gormley, E.P., Bradley, D.G. :
A genome wide association scan of bovine tuberculosis susceptibility in Holstein-Friesian dairy cattle. PLoS One 7:e30545, 2012. Pubmed reference: 22355315 . DOI: 10.1371/journal.pone.0030545.
Müller, A., Möller, M., Adams, L.A., Warren, R.M., Hoal, E.G., van Helden, P.D. :
Comparative analysis of a putative tuberculosis-susceptibility gene, MC3R, and pseudogene sequences in cattle, African buffalo, hyena, rhinoceros and other African bovids and ruminants. Cytogenet Genome Res 136:117-22, 2012. Pubmed reference: 22286663 . DOI: 10.1159/000335464.
Sun, L., Song, Y., Riaz, H., Yang, H., Hua, G., Guo, A., Yang, L. :
Polymorphisms in toll-like receptor 1 and 9 genes and their association with tuberculosis susceptibility in Chinese Holstein cattle. Vet Immunol Immunopathol 147:195-201, 2012. Pubmed reference: 22572235 . DOI: 10.1016/j.vetimm.2012.04.016.
Vordermeier, M., Ameni, G., Berg, S., Bishop, R., Robertson, B.D., Aseffa, A., Hewinson, R.G., Young, D.B. :
The influence of cattle breed on susceptibility to bovine tuberculosis in Ethiopia. Comp Immunol Microbiol Infect Dis 35:227-32, 2012. Pubmed reference: 22304898 . DOI: 10.1016/j.cimid.2012.01.003.
2011 Amos, W., Driscoll, E., Hoffman, J.I. :
Candidate genes versus genome-wide associations: which are better for detecting genetic susceptibility to infectious disease? Proc Biol Sci 278:1183-8, 2011. Pubmed reference: 20926441 . DOI: 10.1098/rspb.2010.1920.
Driscoll, E.E., Hoffman, J.I., Green, L.E., Medley, G.F., Amos, W. :
A preliminary study of genetic factors that influence susceptibility to bovine tuberculosis in the British cattle herd. PLoS One 6:e18806, 2011. Pubmed reference: 21533277 . DOI: 10.1371/journal.pone.0018806.
Kadarmideen, H.N., Ali, A.A., Thomson, P.C., Müller, B., Zinsstag, J. :
Polymorphisms of the SLC11A1 gene and resistance to bovine tuberculosis in African Zebu cattle. Anim Genet 42:656-8, 2011. Pubmed reference: 22035008 . DOI: 10.1111/j.1365-2052.2011.02203.x.
2010 Allen, A.R., Minozzi, G., Glass, E.J., Skuce, R.A., McDowell, S.W., Woolliams, J.A., Bishop, S.C. :
Bovine tuberculosis: the genetic basis of host susceptibility. Proc Biol Sci 277:2737-45, 2010. Pubmed reference: 20519223 . DOI: 10.1098/rspb.2010.0830.
Bermingham, M.L., More, S.J., Good, M., Cromie, A.R., Higgins, I.M., Berry, D.P. :
Genetic correlations between measures of Mycobacterium bovis infection and economically important traits in Irish Holstein-Friesian dairy cows. J Dairy Sci 93:5413-22, 2010. Pubmed reference: 20965357 . DOI: 10.3168/jds.2009-2925.
Brotherstone, S., White, I.M., Coffey, M., Downs, S.H., Mitchell, A.P., Clifton-Hadley, R.S., More, S.J., Good, M., Woolliams, J.A. :
Evidence of genetic resistance of cattle to infection with Mycobacterium bovis. J Dairy Sci 93:1234-42, 2010. Pubmed reference: 20172243 . DOI: 10.3168/jds.2009-2609.
LoBue, P.A., Enarson, D.A., Thoen, C.O. :
Tuberculosis in humans and animals: an overview. Int J Tuberc Lung Dis 14:1075-8, 2010. Pubmed reference: 20819249 .
2009 Bermingham, M.L., More, S.J., Good, M., Cromie, A.R., Higgins, I.M., Brotherstone, S., Berry, D.P. :
Genetics of tuberculosis in Irish Holstein-Friesian dairy herds. J Dairy Sci 92:3447-56, 2009. Pubmed reference: 19528623 . DOI: 10.3168/jds.2008-1848.
2008 Naranjo, V., Acevedo-Whitehouse, K., Vicente, J., Gortazar, C., de la Fuente, J. :
Influence of methylmalonyl-CoA mutase alleles on resistance to bovine tuberculosis in the European wild boar (Sus scrofa). Anim Genet 39:316-20, 2008. Pubmed reference: 18454807 . DOI: 10.1111/j.1365-2052.2008.01725.x.
2007 Morris, C.A. :
A review of genetic resistance to disease in Bos taurus cattle. Vet J 174:481-91, 2007. Pubmed reference: 17095270 . DOI: 10.1016/j.tvjl.2006.09.006.
1986 Pugh, G.W., McDonald, T.J., Kopecky, K.E., Kvasnicka, W.G. :
Infectious bovine keratoconjunctivitis: evidence for genetic modulation of resistance in purebred Hereford cattle. Am J Vet Res 47:885-9, 1986. Pubmed reference: 3516033 .
1981 Petukhov, V.L. :
[Genetics of cattle resistance to tuberculosis. I. The age of having the disease, milk productivity and the maternal influence on the incidence of the infection in progeny]. Genetika 17:1088-94, 1981. Pubmed reference: 7195860 .
1958 Bo, G., Secchi, A. :
[Natural factors in resistance to tuberculosis. 3. Resistance of cattle, horses and dogs to tuberculosis]. G Batteriol Virol Immunol 51:47-53, 1958. Pubmed reference: 13586611 .

Edit History

  • Created by Frank Nicholas on 15 Jun 2013
  • Changed by Imke Tammen2 on 03 Dec 2020
  • Changed by Imke Tammen2 on 25 Jun 2021
  • Changed by Imke Tammen2 on 11 Aug 2021
  • Changed by Imke Tammen2 on 28 Aug 2021