OMIA 001888-9823 : Muscular dystrophy, Becker type in Sus scrofa

In other species: dog

Possibly relevant human trait(s) and/or gene(s) (MIM number): 300376 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: This disorder was first reported (in a single pig) by Horiuchi et al. (2013).

Schwarz et al. (2021): “In Austria, routine meat inspection identified “gluteal muscles infiltrated by fat and muscle tissue obviously being replaced by fat in two different slaughter pigs. … The two muscle samples were investigated histopathologically and diagnosed with fatty muscular dystrophy. The results of routine histopathology were confirmed by dystrophin-specific immunohistochemistry. Sex of the two affected animals was determined retrospectively using a PCR-based protocol and resulted in one male and one female pig. A survey to determine the prevalence of fatty muscular disorders of pork revealed that this phenomenon gets frequently observed in Styria, but also occurs in Upper Austria and Lower Austria. Mostly gluteal and lumbal muscles were affected and approximately 20-40% of the affected muscles were replaced by fat.” A genetic cause was considered by the authors, as the disease showed similarity to Becker muscular dystrophy and the previously reported case in Japan (Horiuchi et al., 2013). Further research is required.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Gaina, G., Popa Gruianu, A. :
Muscular dystrophy: Experimental animal models and therapeutic approaches (Review). Exp Ther Med 21:610, 2021. Pubmed reference: 33936267. DOI: 10.3892/etm.2021.10042.
Schwarz, L., Schöner, C., Brunthaler, R., Weissenböck, H., Bernreiter-Hofer, T., Wallner, B., Ladinig, A. :
Investigations on the occurrence of a muscular disorder in Austrian slaughter pigs. Porcine Health Manag 7:51, 2021. Pubmed reference: 34465383. DOI: 10.1186/s40813-021-00230-1.
2014 Fortunato, M.J., Ball, C.E., Hollinger, K., Patel, N.B., Modi, J.N., Rajasekaran, V., Nonneman, D.J., Ross, J.W., Kennedy, E.J., Selsby, J.T., Beedle, A.M. :
Development of rabbit monoclonal antibodies for detection of alpha-dystroglycan in normal and dystrophic tissue. PLoS One 9:e97567, 2014. Pubmed reference: 24824861. DOI: 10.1371/journal.pone.0097567.
Hollinger, K., Yang, C.X., Montz, R.E., Nonneman, D., Ross, J.W., Selsby, J.T. :
Dystrophin insufficiency causes selective muscle histopathology and loss of dystrophin-glycoprotein complex assembly in pig skeletal muscle. FASEB J 28:1600-9, 2014. Pubmed reference: 24347611. DOI: 10.1096/fj.13-241141.
2013 Horiuchi, N., Aihara, N., Mizutani, H., Kousaka, S., Nagafuchi, T., Ochiai, M., Ochiai, K., Kobayashi, Y., Furuoka, H., Asai, T., Oishi, K. :
Becker muscular dystrophy-like myopathy regarded as so-called "fatty muscular dystrophy" in a pig: A case report and its diagnostic method. J Vet Med Sci :, 2013. Pubmed reference: 24162004.

Edit History

  • Created by Frank Nicholas on 06 Nov 2013
  • Changed by Frank Nicholas on 06 Nov 2013
  • Changed by Imke Tammen2 on 17 Aug 2021
  • Changed by Imke Tammen2 on 03 Sep 2021