OMIA:001894-9615 : Cervical vertebral compressive myelopathy in Canis lupus familiaris (dog)

In other species: mountain zebra , horse , sheep

Categories: Nervous system phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Also known as hereditary ataxia

Species-specific name: Cervical spondylomyelopathy; wobbler syndrome

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breeds: Borzoi (Dog) (VBO_0200197), Doberman Pinscher (Dog) (VBO_0200442), Great Dane (Dog) (VBO_0200623), Mastiff (Dog) (VBO_0200867).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001894-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Wade, C.M., Nuttall, R., Liu, S. :
Comprehensive analysis of geographic and breed-purpose influences on genetic diversity and inherited disease risk in the Doberman dog breed. Canine Med Genet 10:7, 2023. Pubmed reference: 37277858. DOI: 10.1186/s40575-023-00130-3.
2015 Martin-Vaquero, P., da Costa, R.C. :
Body conformation in Great Danes with and without clinical signs of cervical spondylomyelopathy. Vet J 203:219-22, 2015. Pubmed reference: 25555338. DOI: 10.1016/j.tvjl.2014.12.003.
2011 De Decker, S., Gielen, IM., Duchateau, L., van Bree, HJ., Waelbers, T., Bavegems, V., Van Ham, LM. :
Morphometric dimensions of the caudal cervical vertebral column in clinically normal Doberman Pinschers, English Foxhounds and Doberman Pinschers with clinical signs of disk-associated cervical spondylomyelopathy. Vet J , 2011. Pubmed reference: 21257325. DOI: 10.1016/j.tvjl.2010.12.017.
2010 da Costa, RC. :
Cervical spondylomyelopathy (wobbler syndrome) in dogs. Vet Clin North Am Small Anim Pract 40:881-913, 2010. Pubmed reference: 20732597. DOI: 10.1016/j.cvsm.2010.06.003.
2002 Davidson, E.B., Bahr, R.J., Ritchey, J.W., Lorenz, M.D. :
Hindlimb ataxia in an English bulldog Veterinary Medicine 97:265-+, 2002.
2000 Sumano, E., Bermudez, E., Obregon, K. :
Treatment of wobbler syndrome in dogs with electroacupuncture Deutsche Tierarztliche Wochenschrift 107:231-235, 2000. Pubmed reference: 10916938.
1999 McKee, W.M., Butterworth, S.J., Scott, H.W. :
Management of cervical spondylopathy-associated intervertebral disc protrusions using metal washers in 78 dogs Journal of Small Animal Practice 40:465-472, 1999. Pubmed reference: 10587923.
1998 Queen, J.P., Coughlan, A.R., May, C., Bennett, D., Penderis, J. :
Management of disc-associated wobbler syndrome with a partial slot fenestration and position screw technique Journal of Small Animal Practice 39:131-136, 1998. Pubmed reference: 9551381.
1995 Burbidge, H.M. :
A review of wobbler syndrome in the Doberman Pinscher [Review] Australian Veterinary Practitioner 25:147-156, 1995.
Sharp, N.J.H., Cofone, M., Robertson, I.D., Decarlo, A., Smith, G.K., Thrall, D.E. :
Computed tomography in the evaluation of caudal cervical spondylomyelopathy of the Doberman Pinscher Veterinary Radiology & Ultrasound 36:100-108, 1995.
1994 Burbidge, H.M., Pfeiffer, D.U., Blair, H.T. :
Canine Wobbler-Syndrome - A Study of the Dobermann-Pinscher in New-Zealand New Zealand Veterinary Journal 42:221-228, 1994.
Denis, B., Marescaux, L. :
Heredity of a Medullary Cervical Ataxia Syndrome (Wobbler Syndrome) in the Mastiff Recueil de Medecine Veterinaire 170:245-247, 1994.
Seim, H.B. :
Wobbler Syndrome in the Doberman-Pinscher (Reprinted) Canine Practice 19:23-26, 1994.
Thilagar, S., Mohammed, M.S.D.M., Gopal, M.S. :
Cervical Spondylomyelopathy (Wobbler Syndrome) in the Dog Indian Veterinary Journal 71:918-920, 1994.
1993 Mandigers, P.J.J., Vannes, J.J., Knol, B.W., Ubbink, G.J., Gruys, E. :
Hereditary Kooiker Dog Ataxia Tijdschrift Voor Diergeneeskunde 118:S65, 1993. Pubmed reference: 8480326.
1992 Sharp, N.J.H., Wheeler, S.J., Cofone, M. :
Radiological Evaluation of Wobbler Syndrome - Caudal Cervical Spondylomy-Elopathy Journal of Small Animal Practice 33:491-499, 1992.
1988 Jaggy, A., Gaillard, C., Lang, J., Vandevelde, M. :
Hereditary cervical spondylopathy (wobbler syndrome) in the Borzoi dog Journal of the American Animal Hospital Association 24:453-460, 1988.
1962 Bjorck, G., Mair, W., Olsson, S.G., Sourander, P. :
Hereditary ataxia in Fox Terriers Acta Neuropathologia 1 supplement:45-48, 1962.
1957 Bjorck, G., Dryendahl, S., Olsson, S.E. :
Hereditary ataxia in smooth haired Fox Terriers Veterinary Record 69:871-876, 1957.

Edit History

  • Created by Carrie Finno on 11 Dec 2013
  • Changed by Carrie Finno on 11 Dec 2013
  • Changed by Imke Tammen2 on 07 Jun 2023