OMIA 001894-9796 : Cervical vertebral compressive myelopathy in Equus caballus

In other species: dog , mountain zebra

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Also known as hereditary ataxia

Species-specific name: Cervical vertebral malformation and malarticulation; cervical vertebral stenotic myelopathy; cervical stenotic myelopathy; “wobbler’s” syndrome; wobbler; wobbling; wobbles

Inheritance: From the results of an extensive pedigree analysis of 121 cases in US Thoroughbreds, Dymock (1950) reported that "the evidence suggests the recessive nature of the defect" but was careful to note exceptions to single-locus inheritance. He concluded that "The complete genetic interpretation must await further observation and research." Falco et al. (1976) reported "no evidence of a genetic basis was found" in UK Thoroughbreds.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
1994 Tomizawa, N., Nishimura, R., Sasaki, N., Nakayama, H., Kadosawa, T., Senba, H., Takeuchi, A. :
Relationships Between Radiography of Cervical Vertebrae and Histopathology of the Cervical Cord in 19 Wobbling Foals Journal of Veterinary Medical Science 56:227-233, 1994. Pubmed reference: 8075209.
1989 Anon. :
Success for equine wobbler surgery. Aust Vet J 66:suppl 8, 1989. Pubmed reference: 2930385.
1980 Spaul, G., Palmer, A.C., Allsopp, J.D., Hughes-Parry, E.M. :
Wobbler syndrome (cervical stenosis) in a Percheron colt. Vet Rec 107:362, 1980. Pubmed reference: 7210440.
1978 Kero, T., Kuussaari, J. :
Spinal ataxia in the horse. A case report. Nord Vet Med 30:546-51, 1978. Pubmed reference: 733483.
1976 Falco, M.J., Whitwell, K., Palmer, A.C. :
An investigation into the genetics of 'wobbler disease' in thoroughbred horses in Britain Equine Veterinary Journal 8:165-169, 1976. Pubmed reference: 976231.
1974 Montali, R.G., Bush, M., Sauer, R.M., Gray, C.W., Xanten, W.A. :
Spinal ataxia in Zebras: comparison with wobbler syndrome in horses Veterinary Pathology 11:68-78, 1974. Pubmed reference: 4432358.
1972 Rooney, J.R. :
Etiology of the wobbler syndrome. Mod Vet Pract 53:42, 1972. Pubmed reference: 5072971.
1967 Fraser, H., Palmer, A.C. :
Equine incoordination and wobbler disease of young horses Veterinary Record 80:338-355, 1967. Pubmed reference: 6067622.
1950 Dimock, W.W. :
"Wobbles" an hereditary disease in horses. J Hered 41:319-23, 1950. Pubmed reference: 14824538.

Edit History


  • Created by Carrie Finno on 11 Dec 2013
  • Changed by Carrie Finno on 11 Dec 2013