OMIA:001894-9796 : Cervical vertebral compressive myelopathy in Equus caballus (horse)

In other species: dog , mountain zebra , sheep

Categories: Skeleton phene (incl. short stature & teeth) , Nervous system phene

Single-gene trait/disorder: unknown

Disease-related: yes

Cross-species summary: Also known as hereditary ataxia

Species-specific name: Cervical vertebral malformation and malarticulation; cervical vertebral stenotic myelopathy; cervical stenotic myelopathy; “wobbler’s” syndrome; wobbler; wobbling; wobbles

Inheritance: From the results of an extensive pedigree analysis of 121 cases in US Thoroughbreds, Dymock (1950) reported that "the evidence suggests the recessive nature of the defect" but was careful to note exceptions to single-locus inheritance. He concluded that "The complete genetic interpretation must await further observation and research." Falco et al. (1976) reported "no evidence of a genetic basis was found" in UK Thoroughbreds.

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2013). OMIA:001894-9796: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Dyson, S., Quiney, L., Phillips, K., Zheng, S., Aleman, M. :
Radiological abnormalities of the cervicothoracic vertebrae in Warmblood horses with primary neck-related clinical signs versus controls. Vet Radiol Ultrasound 65:755-768, 2024. Pubmed reference: 39161192. DOI: 10.1111/vru.13420.
May-Davis, S., Eckelbarger, P.B., Dzingle, D., Saber, E. :
Characterization and association of the missing ventral tubercle(s) from the sixth cervical vertebra and transpositions on the ventral surface of the seventh cervical vertebra in modern Equus ferus caballus. Animals (Basel) 14:1830, 2024. Pubmed reference: 38929448. DOI: 10.3390/ani14121830.
2023 Donnelly, C.G., Johnson, A.L., Reed, S., Finno, C.J. :
Cerebrospinal fluid and serum proteomic profiles accurately distinguish neuroaxonal dystrophy from cervical vertebral compressive myelopathy in horses. J Vet Intern Med 37:689-696, 2023. Pubmed reference: 36929645. DOI: 10.1111/jvim.16660.
Mannaa, M., Shamaa, A.A., Shawky, A., Hassan, I.M., Refaey, A.M., Abu-Seida, A.M. :
A novel surgical technique for treatment of cervical vertebral stenotic myelopathy (wobbler syndrome) in a filly. J Equine Vet Sci 126:104493, 2023. Pubmed reference: 37072073. DOI: 10.1016/j.jevs.2023.104493.
1994 Tomizawa, N., Nishimura, R., Sasaki, N., Nakayama, H., Kadosawa, T., Senba, H., Takeuchi, A. :
Relationships Between Radiography of Cervical Vertebrae and Histopathology of the Cervical Cord in 19 Wobbling Foals J Vet Med Sci 56:227-33, 1994. Pubmed reference: 8075209. DOI: 10.1292/jvms.56.227.
1989 Anon. :
Success for equine wobbler surgery. Aust Vet J 66:suppl 8, 1989. Pubmed reference: 2930385.
1980 Spaul, G., Palmer, A.C., Allsopp, J.D., Hughes-Parry, E.M. :
Wobbler syndrome (cervical stenosis) in a Percheron colt. Vet Rec 107:362, 1980. Pubmed reference: 7210440. DOI: 10.1136/vr.107.15.362-a.
1978 Kero, T., Kuussaari, J. :
Spinal ataxia in the horse. A case report. Nord Vet Med 30:546-51, 1978. Pubmed reference: 733483.
1976 Falco, M.J., Whitwell, K., Palmer, A.C. :
An investigation into the genetics of 'wobbler disease' in thoroughbred horses in Britain Equine Vet J 8:165-9, 1976. Pubmed reference: 976231. DOI: 10.1111/j.2042-3306.1976.tb03331.x.
1974 Montali, R.G., Bush, M., Sauer, R.M., Gray, C.W., Xanten, W.A. :
Spinal ataxia in Zebras: comparison with wobbler syndrome in horses Vet Pathol 11:68-78, 1974. Pubmed reference: 4432358. DOI: 10.1177/030098587401100108.
1972 Rooney, J.R. :
Etiology of the wobbler syndrome. Mod Vet Pract 53:42, 1972. Pubmed reference: 5072971.
1967 Fraser, H., Palmer, A.C. :
Equine incoordination and wobbler disease of young horses Vet Rec 80:338-55, 1967. Pubmed reference: 6067622. DOI: 10.1136/vr.80.11.338.
1950 Dimock, W.W. :
"Wobbles" an hereditary disease in horses. J Hered 41:319-23, 1950. Pubmed reference: 14824538. DOI: 10.1093/oxfordjournals.jhered.a106074.

Edit History


  • Created by Carrie Finno on 11 Dec 2013
  • Changed by Carrie Finno on 11 Dec 2013