OMIA:001905-9940 : Johne's disease, susceptibility/resistance to in Ovis aries (sheep)

In other species: ass (donkey) , Arabian camel , taurine cattle , indicine cattle (zebu) , goat

Categories: Immune system phene

Single-gene trait/disorder: unknown

Disease-related: no

Cross-species summary: Susceptibility or resistance to Johne's disease.  Johne's disease, also called paratuberculosis, is caused by the bacterium Mycobacterium avium subspecies paratuberculosis (MAP).

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Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:001905-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2026 Arrazuria, R., Alonso-Hearn, M., Juste, R.A., Facciuolo, A., Koets, A.P., Köhler, H., Guatteo, R., Grant, I.R., Plain, K., Mc Aloon, C.G., Graham, D., Verdugo, C., Ricchi, M., Mundo, S.L., Elguezabal, N. :
Advances in paratuberculosis research and control: a comprehensive expert review. BMC Vet Res , 2026. Pubmed reference: 42432668. DOI: 10.1186/s12917-026-05717-z.
Worsley, L., Ridler, A., Wedley, A., Urbaniec, J., Davies, P. :
Exploration of the prevalence and production impact of Mycobacterium avium subsp. paratuberculosis (MAP) infection in the sheep populations of Great Britain and New Zealand. Vet J 316:106600, 2026. Pubmed reference: 41707828. DOI: 10.1016/j.tvjl.2026.106600.
2025 Mataragka, A., Klavdianos Papastathis, A., Ikonomopoulos, J. :
Association of SLC11A1 3'UTR (GT)n microsatellite polymorphisms with resistance to paratuberculosis in sheep. Pathogens 14:1150, 2025. Pubmed reference: 41305387. DOI: 10.3390/pathogens14111150.
Tharwat, M., Ali, H., Alkheraif, A.A. :
Paratuberculosis in sheep and goats: Pathogenesis, diagnostic findings, and control strategies. Open Vet J 15:1-7, 2025. Pubmed reference: 40092194. DOI: 10.5455/OVJ.2025.v15.i1.1.
2024 Kravitz, A., Liao, M., Morota, G., Tyler, R., Cockrum, R., Manohar, B.M., Ronald, B.S.M., Collins, M.T., Sriranganathan, N. :
Retrospective single nucleotide polymorphism analysis of host resistance and susceptibility to ovine Johne's disease using restored FFPE DNA. Int J Mol Sci 25:7748, 2024. Pubmed reference: 39062990. DOI: 10.3390/ijms25147748.
Usai, M.G., Casu, S., Sechi, T., Salaris, S.L., Miari, S., Mulas, G., Cancedda, M.G., Ligios, C., Carta, A. :
Advances in understanding the genetic architecture of antibody response to paratuberculosis in sheep by heritability estimate and LDLA mapping analyses and investigation of candidate regions using sequence-based data. Genet Sel Evol 56:5, 2024. Pubmed reference: 38200416. DOI: 10.1186/s12711-023-00873-4.
2021 Kravitz, A., Pelzer, K., Sriranganathan, N. :
The paratuberculosis paradigm examined: A review of host genetic resistance and innate immune fitness in Mycobacterium avium subsp. paratuberculosis infection. Front Vet Sci 8:721706, 2021. Pubmed reference: 34485444. DOI: 10.3389/fvets.2021.721706.
Yaman, Y., Aymaz, R., Keleş, M., Bay, V., Ün, C., Heaton, M.P. :
Association of TLR2 haplotypes encoding Q650 with reduced susceptibility to ovine Johne's disease in Turkish sheep. Sci Rep 11:7088, 2021. Pubmed reference: 33782507. DOI: 10.1038/s41598-021-86605-4.
Yaman, Y., Aymaz, R., Keleş, M., Bay, V., Hatipoğlu, E., Kaptan, C., Başkurt, A., Yilmaz, O., Heaton, M.P. :
Evaluation of CD109, PCP4 and SEMA3D genes for their association with ovine Johne's disease in Turkish sheep. Anim Biotechnol 32:519-525, 2021. Pubmed reference: 33612073. DOI: 10.1080/10495398.2021.1887880.
2016 Moioli, B. et al. :
Genomic scan for identifying candidate genes for paratuberculosis resistance in sheep. Animal Production Science 56:1046-1055, 2016. DOI: 10.1071/AN14826.
Nicol, L., Gossner, A., Watkins, C., Chianini, F., Dalziel, R., Hopkins, J. :
Variations in IL-23 and IL-25 receptor gene structure, sequence and expression associated with the two disease forms of sheep paratuberculosis. Vet Res 47:27, 2016. Pubmed reference: 26861902. DOI: 10.1186/s13567-016-0314-4.
2015 Bishop, S.C. :
Genetic resistance to infections in sheep. Vet Microbiol 181:2-7, 2015. Pubmed reference: 26260859. DOI: 10.1016/j.vetmic.2015.07.013.
2013 Vir Singh, S., Dhama, K., Chaubey, K.K., Kumar, N., Singh, P.K., Sohal, J.S., Gupta, S., Vir Singh, A., Verma, A.K., Tiwari, R. :
Impact of host genetics on susceptibility and resistance to Mycobacterium avium subspecies Paratuberculosis infection in domestic ruminants. Pak J Biol Sci 16:251-66, 2013. Pubmed reference: 24498788. DOI: 10.3923/pjbs.2013.251.266.
1996 Chiodini, R.J. :
Immunology: resistance to paratuberculosis. Vet Clin North Am Food Anim Pract 12:313-43, 1996. Pubmed reference: 8828108. DOI: 10.1016/s0749-0720(15)30409-6.

Edit History


  • Created by Frank Nicholas on 08 Feb 2014
  • Changed by Imke Tammen on 19 Apr 2021
  • Changed by Imke Tammen on 17 Sep 2021