OMIA 001920-27706 : Abortion, GHRH-related in Micropterus salmoides

Mendelian trait/disorder: yes

Mode of inheritance: Recessive Embryonic Lethal

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2014

Molecular basis: In the course of sequencing the GHRH gene in largemouth bass, Ma et al. (2014) identified a 66bp deletion (c.-923_-858del) in the 5' flanking region of the GHRH gene, and via segregation studies, showed that it is an autosomal recessive embryonic lethal. The heterozygote does not differ significantly from the normal homozygote in growth traits.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
GHRH Micropterus salmoides - no genomic information (-..-) GHRH Ensembl

Variants

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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
Abortion due to deletion in GHRH GHRH deletion, gross (>20) a 66bp deletion (c.-923_-858del) in the 5' flanking region of the GHRH gene in an autosomal recessive embryonic lethal 2014 24697798

Reference


2014 Ma, D.M., Han, L.Q., Bai, J.J., Li, S.J., Fan, J.J., Yu, L.Y., Quan, Y.C. :
A 66-bp deletion in growth hormone releasing hormone gene 5'-flanking region with largemouth bass recessive embryonic lethal. Anim Genet :, 2014. Pubmed reference: 24697798. DOI: 10.1111/age.12143.

Edit History


  • Created by Frank Nicholas on 09 Apr 2014
  • Changed by Frank Nicholas on 09 Apr 2014