OMIA 001956-9031 : Resistance/susceptibility to avian sarcoma and leukosis viruses, subgroup J in Gallus gallus

Possibly relevant human trait(s) and/or gene(s) (MIM number): 107310 (gene)

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: unknown

Key variant known: yes

Year key variant first reported: 2020

Species-specific description: Chai and Bates (2006) identified the receptor for subgroup J viruses as being the Na+/H+ exchanger type 1 (chNHE1).

Molecular basis: Using "precise CRISPR/Cas9 gene editing", Koslová et al. (2020) deleted the triplet for the critical receptor amino acid (W38) in the chNHE1 gene that encodes functional receptor for subgroup J leukosis virus, creating ΔW38. The authors reported that "The resistance to ALV-J was examined both in vitro and in vivo, and the ΔW38 homozygous chickens tested ALV-J-resistant, in contrast to ΔW38 heterozygotes and wild-type birds, which were ALV-J-susceptible. Deletion of W38 did not manifest any visible side effect."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 Gallus gallus 23 NC_052554.1 (2256836..2237984) SLC9A1 Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2022 Mo, G., Hu, B., Zhang, Q., Ruan, Z., Li, W., Liang, J., Shen, Y., Mo, Z., Zhang, Z., Wu, Z., Shi, M., Zhang, X. :
dPRLR causes differences in immune responses between early and late feathering chickens after ALV-J infection. Vet Res 53:1, 2022. Pubmed reference: 34998433. DOI: 10.1186/s13567-021-01016-7.
2021 Kheimar, A., Klinger, R., Bertzbach, L.D., Sid, H., Yu, Y., Conradie, A.M., Schade, B., Böhm, B., Preisinger, R., Nair, V., Kaufer, B.B., Schusser, B. :
A genetically engineered commercial chicken line is resistant to highly pathogenic avian leukosis virus subgroup J. Microorganisms 9:, 2021. Pubmed reference: 34069313. DOI: 10.3390/microorganisms9051066.
2020 Hellmich, R, Sid, H, Lengyel, K, Flisikowski, K, Schlickenrieder, A, Bartsch, D, Thoma, T, Bertzbach, LD, Kaufer, BB, Nair, V, Preisinger, R, Schusser, B :
Acquiring resistance against a retroviral infection via CRISPR/Cas9 targeted genome editing in a commercial chicken line Front. Genome Ed. 2:3, 2020. DOI: https://doi.org/10.3389/fgeed.2020.00003.
Koslová, A., Trefil, P., Mucksová, J., Reinišová, M., Plachý, J., Kalina, J., Kučerová, D., Geryk, J., Krchlíková, V., Lejčková, B., Hejnar, J. :
Precise CRISPR/Cas9 editing of the NHE1 gene renders chickens resistant to the J subgroup of avian leukosis virus. Proc Natl Acad Sci U S A :, 2020. Pubmed reference: 31964810. DOI: 10.1073/pnas.1913827117.
2018 Guan, X., Zhang, Y., Yu, M., Ren, C., Gao, Y., Yun, B., Liu, Y., Wang, Y., Qi, X., Liu, C., Cui, H., Zhang, Y., Gao, L., Li, K., Pan, Q., Zhang, B., Wang, X., Gao, Y. :
Residues 28 to 39 of the Extracellular Loop 1 of Chicken Na<sup>+</sup>/H<sup>+</sup> Exchanger Type I Mediate Cell Binding and Entry of Subgroup J Avian Leukosis Virus. J Virol 92:, 2018. Pubmed reference: 29070685. DOI: 10.1128/JVI.01627-17.
2016 Reinišová, M., Plachý, J., Kučerová, D., Šenigl, F., Vinkler, M., Hejnar, J. :
Genetic Diversity of NHE1, Receptor for Subgroup J Avian Leukosis Virus, in Domestic Chicken and Wild Anseriform Species. PLoS One 11:e0150589, 2016. Pubmed reference: 26978658. DOI: 10.1371/journal.pone.0150589.
2013 Cai, L.M., Wang, Z.Z., Wang, Y.M., Shen, Y.w., Wei, R.R., Cheng, Z.Q. :
[The relationship of virus load, receptor expression and tumor spectrum in layer chickens infected by ALV-J]. Bing Du Xue Bao 29:515-21, 2013. Pubmed reference: 24386840.
Kucerová, D., Plachy, J., Reinisová, M., Senigl, F., Trejbalová, K., Geryk, J., Hejnar, J. :
Nonconserved tryptophan 38 of the cell surface receptor for subgroup J avian leukosis virus discriminates sensitive from resistant avian species. J Virol 87:8399-407, 2013. Pubmed reference: 23698309. DOI: 10.1128/JVI.03180-12.
2006 Chai, N., Bates, P. :
Na+/H+ exchanger type 1 is a receptor for pathogenic subgroup J avian leukosis virus. Proc Natl Acad Sci U S A 103:5531-6, 2006. Pubmed reference: 16567631. DOI: 10.1073/pnas.0509785103.

Edit History


  • Created by Frank Nicholas on 27 Apr 2015
  • Changed by Frank Nicholas on 27 Apr 2015
  • Changed by Frank Nicholas on 24 Jan 2020
  • Changed by Frank Nicholas on 15 May 2020
  • Changed by Imke Tammen2 on 10 Jun 2021
  • Changed by Imke Tammen2 on 30 Jan 2022