OMIA 001968-9615 : Height, HMGA2-associated body-size variation in Canis lupus familiaris

In other species: horse

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 600698 (gene) , 611547 (trait) , 618908 (trait)

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: no

Key variant known: no

Cross-species summary: Height has frequently been used as a textbook example for a polygenic trait. In humans, hundreds of loci with relatively small effects have been identified. In several domestic animal species, a handful of genetic loci has been repeatedly found to have comparatively large effects on height and/or body size.

Molecular basis: Rimbault et al. (2013) identified a "SNP in the 5′ UTR of HMGA2" that has a substantial effect on body size.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
HMGA2 high mobility group AT-hook 2 Canis lupus familiaris 10 NC_051814.1 (8459176..8604625) HMGA2 Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2019 Hayward, J.J., White, M.E., Boyle, M., Shannon, L.M., Casal, M.L., Castelhano, M.G., Center, S.A., Meyers-Wallen, V.N., Simpson, K.W., Sutter, N.B., Todhunter, R.J., Boyko, A.R. :
Imputation of canine genotype array data using 365 whole-genome sequences improves power of genome-wide association studies. PLoS Genet 15:e1008003, 2019. Pubmed reference: 31525180. DOI: 10.1371/journal.pgen.1008003.
2015 Webster, M.T., Kamgari, N., Perloski, M., Hoeppner, M.P., Axelsson, E., Hedhammar, Å., Pielberg, G., Lindblad-Toh, K. :
Linked genetic variants on chromosome 10 control ear morphology and body mass among dog breeds. BMC Genomics 16:474, 2015. Pubmed reference: 26100605. DOI: 10.1186/s12864-015-1702-2.
2013 Rimbault, M., Beale, H.C., Schoenebeck, J.J., Hoopes, B.C., Allen, J.J., Kilroy-Glynn, P., Wayne, R.K., Sutter, N.B., Ostrander, E.A. :
Derived variants at six genes explain nearly half of size reduction in dog breeds. Genome Res :, 2013. Pubmed reference: 24026177. DOI: 10.1101/gr.157339.113.

Edit History


  • Created by Frank Nicholas on 23 Apr 2016
  • Changed by Frank Nicholas on 23 Apr 2016