OMIA:001990-10036 : Cancer, TP53-related in Mesocricetus auratus (golden hamster) |
In other species: crab-eating macaque , dog , pig
Categories: Neoplasm
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 109800 (trait) , 114480 (trait) , 137215 (trait) , 601626 (trait) , 211980 (trait) , 260350 (trait) , 614470 (trait) , 202300 (trait) , 114500 (trait) , 114550 (trait) , 607107 (trait) , 259500 (trait) , 614740 (trait) , 137800 (trait) , 191170 (gene) , 190070 (gene) , 151623 (trait)
Mendelian trait/disorder: yes
Disease-related: yes
Key variant known: no
Species-specific description: Miao et al. (2021) describe a cancer phenotype in TP53 knockout golden Syrian hamsters. This phene includes references to studies involving genetically modified organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
---|---|---|---|---|---|---|
Tp53 | tumor protein p53 | Mesocricetus auratus | NW_024429191.1 (48447627..48459485) | Tp53 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:001990-10036: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
2021 | Miao, J., Li, R., Wettere, A.J.V., Guo, H., Tabaran, A.F., O'Sullivan, M.G., Carlson, T., Scott, P.M., Chen, K., Gao, D., Li, H., Wang, Y., Wang, Z., Cormier, R.T. : |
Cancer spectrum in TP53-deficient golden Syrian hamsters: A new model for Li-Fraumeni syndrome. J Carcinog 20:18, 2021. Pubmed reference: 34729050. DOI: 10.4103/jcar.jcar_18_21. |
Edit History
- Created by Imke Tammen2 on 08 Nov 2021
- Changed by Imke Tammen2 on 18 Dec 2023
- Changed by Imke Tammen2 on 18 Oct 2024