OMIA 001990-9823 : Cancer model, KRAS and TP53 in Sus scrofa

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 109800 , 114480 , 137215 , 601626 , 211980 , 260350 , 614470 , 202300 , 114500 , 114550 , 607107 , 259500 , 614740 , 137800

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Genetically-modifed organism; GMO

Molecular basis: Sieren et al. (2014) created pigs transgenic for the R167H variant of TP53, equivalent to the human variant R175H that is "one of the most frequent missense mutations in sporadic [human] tumors". Homozygotes for this variant "developed lymphomas and osteogenic tumors, recapitulating the tumor types observed in mice and humans expressing orthologous TP53 mutant alleles".

Schook et al. (2015) developed a line of pigs transgenic for the same TP53 variant and for another oncogenic variant, namely G12D in the KRAS gene.

Associated genes:

Symbol Description Species Chr Location OMIA gene details page Other Links
TP53 tumor protein p53 Sus scrofa 12 NC_010454.4 (52953786..52939643) TP53 Homologene, Ensembl, NCBI gene
KRAS Kirsten rat sarcoma viral oncogene homolog Sus scrofa 5 NC_010447.5 (48508774..48546260) KRAS Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2015 Schook, L.B., Collares, T.V., Hu, W., Liang, Y., Rodrigues, F.M., Rund, L.A., Schachtschneider, K.M., Seixas, F.K., Singh, K., Wells, K.D., Walters, E.M., Prather, R.S., Counter, C.M. :
A Genetic Porcine Model of Cancer. PLoS One 10:e0128864, 2015. Pubmed reference: 26132737. DOI: 10.1371/journal.pone.0128864.
2014 Sieren, J.C., Meyerholz, D.K., Wang, X.J., Davis, B.T., Newell, J.D., Hammond, E., Rohret, J.A., Rohret, F.A., Struzynski, J.T., Goeken, J.A., Naumann, P.W., Leidinger, M.R., Taghiyev, A., Van Rheeden, R., Hagen, J., Darbro, B.W., Quelle, D.E., Rogers, C.S. :
Development and translational imaging of a TP53 porcine tumorigenesis model. J Clin Invest 124:4052-66, 2014. Pubmed reference: 25105366. DOI: 10.1172/JCI75447.

Edit History


  • Created by Frank Nicholas on 13 Apr 2016
  • Changed by Frank Nicholas on 14 Aug 2016
  • Changed by Frank Nicholas on 08 Aug 2017