OMIA 001990-9541 : Cancer, TP53-related in Macaca fascicularis

In other species: pig , golden hamster

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 109800 (trait) , 114480 (trait) , 137215 (trait) , 601626 (trait) , 211980 (trait) , 260350 (trait) , 614470 (trait) , 202300 (trait) , 114500 (trait) , 114550 (trait) , 607107 (trait) , 259500 (trait) , 614740 (trait) , 137800 (trait) , 191170 (gene) , 190070 (gene) , 151623 (trait)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2015

Species-specific description: Wan et al. (2015) produced the first live p53 homozygous mutant monkey using CRISPR/Cas9 technology.

This study involves genetically modified organisms (GMO).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
TP53 tumor protein p53 Macaca fascicularis 16 NC_052270.1 (69909312..69928293) TP53 Homologene, Ensembl, NCBI gene

Reference


2015 Wan, H., Feng, C., Teng, F., Yang, S., Hu, B., Niu, Y., Xiang, A.P., Fang, W., Ji, W., Li, W., Zhao, X., Zhou, Q. :
One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Res 25:258-261, 2015. Pubmed reference: 25430965. DOI: 10.1038/cr.2014.158.

Edit History


  • Created by Imke Tammen2 on 12 Sep 2022
  • Changed by Imke Tammen2 on 12 Sep 2022