OMIA:001990-9541 : Cancer, TP53-related in Macaca fascicularis |
In other species: pig , golden hamster , dog
Categories: Neoplasm
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 109800 (trait) , 114480 (trait) , 137215 (trait) , 601626 (trait) , 211980 (trait) , 260350 (trait) , 614470 (trait) , 202300 (trait) , 114500 (trait) , 114550 (trait) , 607107 (trait) , 259500 (trait) , 614740 (trait) , 137800 (trait) , 191170 (gene) , 190070 (gene) , 151623 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: yes
Key variant known: yes
Year key variant first reported: 2015
Species-specific description: Wan et al. (2015) produced the first live p53 homozygous mutant monkey using CRISPR/Cas9 technology.
This study involves genetically modified organisms (GMO).
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| TP53 | tumor protein p53 | Macaca fascicularis | 16 | NC_052270.1 (69909312..69928293) | TP53 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:001990-9541: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2015 | Wan, H., Feng, C., Teng, F., Yang, S., Hu, B., Niu, Y., Xiang, A.P., Fang, W., Ji, W., Li, W., Zhao, X., Zhou, Q. : |
| One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Res 25:258-261, 2015. Pubmed reference: 25430965 . DOI: 10.1038/cr.2014.158. |
Edit History
- Changed by Imke Tammen2 on 12 Sep 2022
- Created by Imke Tammen2 on 12 Sep 2022