OMIA 002054-9823 : Cancer, RUNX-related in Sus scrofa

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 151385 (gene) , 601626 (trait) , 601399 (trait)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific description: Susceptibility to tumours in pigs has been created artificially by CRISPR/Cas9-mediated gene targeting of the tumour supressor RUNX3; producing genetically-modified organisms (GMO)

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
RUNX3 runt-related transcription factor 3 Sus scrofa - no genomic information (-..-) RUNX3 Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Zhang, J., Khazalwa, E.M., Abkallo, H.M., Zhou, Y., Nie, X., Ruan, J., Zhao, C., Wang, J., Xu, J., Li, X., Zhao, S., Zuo, E., Steinaa, L., Xie, S. :
The advancements, challenges, and future implications of the CRISPR/Cas9 system in swine research. J Genet Genomics 48:347-360, 2021. Pubmed reference: 34144928. DOI: 10.1016/j.jgg.2021.03.015.
2016 Kang, J.T., Ryu, J., Cho, B., Lee, E.J., Yun, Y.J., Ahn, S., Lee, J., Ji, D.Y., Lee, K., Park, K.W. :
Generation of RUNX3 knockout pigs using CRISPR/Cas9-mediated gene targeting. Reprod Domest Anim :, 2016. Pubmed reference: 27696566. DOI: 10.1111/rda.12775.

Edit History


  • Created by Frank Nicholas on 17 Oct 2016
  • Changed by Imke Tammen2 on 25 Jun 2021