OMIA:002073-9915 : Resistance/susceptibility to Mannheimia haemolytica leukotoxin in Bos indicus (indicine cattle (zebu)) |
In other species: taurine cattle
Categories: Immune system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 600065 (gene)
Mendelian trait/disorder: unknown
Disease-related: yes
Molecular basis: Workman et al. (2018) reported evidence suggesting "that missense variants in the CD18 signal peptide affect Lkt [a M. haemolytica leukotoxin "that binds to the CD18 receptor on leukocytes, initiates lysis, induces inflammation, and causes acute fibrinous bronchopneumonia"] binding, and animals carrying the C 5 allele may be more susceptible to the effects of Lkt."
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002073-9915: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2018 | Workman, A.M., Chitko-McKown, C.G., Smith, T.P.L., Bennett, G.L., Kalbfleisch, T.S., Basnayake, V., Heaton, M.P. : |
| A bovine CD18 signal peptide variant with increased binding activity to Mannheimia hemolytica leukotoxin. F1000Res 7:1985, 2018. Pubmed reference: 30881690. DOI: 10.12688/f1000research.17187.1. |
Edit History
- Created by Imke Tammen2 on 08 Oct 2023
- Changed by Imke Tammen2 on 08 Oct 2023