OMIA:002180-9823 : Abortion, TADA2A-related in Sus scrofa
Categories: Mortality / aging (incl. embryonic lethal)
Possibly relevant human trait(s) and/or gene(s) (MIM number): 602276 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal recessive lethal
Considered a defect: yes
Key variant known: yes
Year key variant first reported: 2019
Cross-species summary: TADA2A is a protein involved in general transcription machinery.
Species-specific name: Haplotype DU1
Species-specific description: Derks et al. (2019) identified five relatively frequent haplotypes for which there was either a deficit or a complete lack of homozygotes in large populations of Landrace (28,085) and Duroc (11,255). One such haplotype (DU1) was found in the Duroc population and is the subject of this entry. Derks et al. (2019) identified that a "splice donor mutation in the TADA2A gene results in embryonic lethality in the Duroc breed". (Edited by Emmi Payten 17/8/2021)
History: This haplotype was first identified in a 2019 study from two commercial pig populations in Norway (Derks et al., 2019). (Edited by Emmi Payten 17/8/2021)
Mapping: Derks et al. (2019): "To identify lethal alleles segregating in the pig populations we examined genotype data from 28,085 (Landrace), and 11,255 (Duroc) animals. All animals were genotyped or imputed to a medium-density 50K SNPchip ... . The genotypes were phased to build haplotypes, and then we applied an overlapping sliding window approach to identify haplotypes that show a deficit in homozygosity ... . The analysis yielded one strong candidate haplotype (DU1) harbouring a lethal recessive allele in the Duroc population, and four candidates in the Landrace population (LA1-4), respectively." (Edited by Emmi Payten 17/8/2021)
Molecular basis: Derks et al. (2019): "Whole genome sequence data from nine DU1 carrier animals revealed 20 variants in high LD .... with the DU1 haplotype ...., of which only one variant is predicted to have high impact. ... [The] splice-donor mutation (12:g.38922102G>A) in the Transcriptional adapter-Ada2 (TADA2A) gene is in complete LD with the DU1 haplotype ... . The mutation affects a conserved GT splice dinucleotide site at the 5’ end of the intron between exons 13 and 14 ... . Carriers display either retention of intron 13 between exon 13-14… or "exon skipping of exon 13, resulting in a frameshift, the addition of a novel methionine, and a premature stop codon in the first codon of exon 14. The mutant mRNA codes for a truncated TADA2A protein lacking the terminal 101 amino acids that includes the conserved SWIRM domain" for DNA binding (Derks et al. 2019). (Edited by Emmi Payten 17/8/2021)
Clinical features: Derks et al. (2019): "analysed the effect of the haplotypes on fertility phenotypes including total number born (TNB), number born alive (NBA), number of stillborn (NSB), and number of mummified piglets (MUM)." The reduction in litter size (total number born) in carrier x carrier matings, compared with carrier x non-carrier matings, was 21.6%. "No significant increase in number of stillborn (NSB) or mummified piglets (MUM) was found, suggesting that homozygotes die very early in pregnancy." (Edited by Emmi Payten 17/8/2021)
Prevalence: Derks et al. (2019) reported the carrier frequency of haplotype DU1 as 9.6%, with zero observed homozygotes.
Breed: Duroc (Pig) (VBO_0001127).
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|TADA2A||transcriptional adaptor 2A||Sus scrofa||12||NC_010454.2 (40847905..40809992)||TADA2A||Homologene, Ensembl , NCBI gene|
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
|OMIA Variant ID||Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Source of Genetic Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Inferred EVA rsID||Year Published||PubMed ID(s)||Acknowledgements|
|1051||Duroc (Pig)||Embryonic lethality||TADA2A||splicing||Naturally occurring variant||Sscrofa11.1||12||g.38922102G>A||splice-donor mutation causing retention of intron 13 or exon skipping of exon 13 (Derks et al., 2019)||2019||30875370|
|2019||Derks, M.F.L., Gjuvsland, A.B., Bosse, M., Lopes, M.S., van Son, M., Harlizius, B., Tan, B.F., Hamland, H., Grindflek, E., Groenen, M.A.M., Megens, H.J., Derks, M.F.L., Gjuvsland, A.B., Bosse, M., Lopes, M.S., van Son, M., Harlizius, B., Tan, B.F., Hamland, H., Grindflek, E., Groenen, M.A.M., Megens, H.J. :|
|Loss of function mutations in essential genes cause embryonic lethality in pigs. PLoS Genet 15:e1008055, 2019. Pubmed reference: 30875370 . DOI: 10.1371/journal.pgen.1008055.|
- Created by Frank Nicholas on 25 Mar 2019
- Changed by Frank Nicholas on 26 Mar 2019
- Changed by Imke Tammen2 on 27 May 2021
- Changed by Imke Tammen2 on 17 Aug 2021
- Changed by Imke Tammen2 on 24 Aug 2021