You are here: OMIA / Search / OMIA:002246 / dog

OMIA:002246-9615 : Height, LCORL-associated body-size variation in Canis lupus familiaris (dog)

In other species: horse , taurine cattle , goat

Categories: Growth / size / body region phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 611799 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: no

Key variant known: no

Markers: Plaissais et al. (2019) reported "a significant association at LCORL in the analysis of both SBW [standard breed weight] and SBH [standard breed weight] (pwald = 4.1 × 10−23 and 2.4 × 10−10, respectively), which are themselves highly correlated traits". A single A insertion into the last exon of the long isoform of LCORL was identified, XM_022416410.1:c.3661_3662insA. The insertion allele was not observed in small dog breeds (<10 kg), had a frequency of 0.16 in medium-sized dog breeds (10-41 kg) and a high frequency of 0.67 in large breeds (>41 kg; Plassais et al. 2019).

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
LCORL ligand dependent nuclear receptor corepressor-like Canis lupus familiaris 3 NC_051807.1 (92125265..92275341) LCORL Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2020). OMIA:002246-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2020 Momozawa, Y., Merveille, A.C., Battaille, G., Wiberg, M., Koch, J., Willesen, J.L., Proschowsky, H.F., Gouni, V., Chetboul, V., Tiret, L., Fredholm, M., Seppälä, E.H., Lohi, H., Georges, M., Lequarré, A.S. :
Genome wide association study of 40 clinical measurements in eight dog breeds. Sci Rep 10:6520, 2020. Pubmed reference: 32300138. DOI: 10.1038/s41598-020-63457-y.
2019 Plassais, J., Kim, J., Davis, B.W., Karyadi, D.M., Hogan, A.N., Harris, A.C., Decker, B., Parker, H.G., Ostrander, E.A. :
Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology. Nat Commun 10:1489, 2019. Pubmed reference: 30940804. DOI: 10.1038/s41467-019-09373-w.

Edit History


  • Created by Frank Nicholas on 13 Feb 2020
  • Changed by Frank Nicholas on 13 Feb 2020
  • Changed by Tosso Leeb on 15 Feb 2020