OMIA:002246-9615 : Height, LCORL-associated body-size variation in Canis lupus familiaris (dog) |
In other species: horse , taurine cattle , goat
Categories: Growth / size / body region phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 611799 (gene)
Single-gene trait/disorder: no
Mode of inheritance: Multifactorial
Disease-related: no
Key variant known: no
Markers: Plaissais et al. (2019) reported "a significant association at LCORL in the analysis of both SBW [standard breed weight] and SBH [standard breed weight] (pwald = 4.1 × 10−23 and 2.4 × 10−10, respectively), which are themselves highly correlated traits". A single A insertion into the last exon of the long isoform of LCORL was identified, XM_022416410.1:c.3661_3662insA. The insertion allele was not observed in small dog breeds (<10 kg), had a frequency of 0.16 in medium-sized dog breeds (10-41 kg) and a high frequency of 0.67 in large breeds (>41 kg; Plassais et al. 2019).
Associated gene:
Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
---|---|---|---|---|---|---|
LCORL | ligand dependent nuclear receptor corepressor-like | Canis lupus familiaris | 3 | NC_051807.1 (92125265..92275341) | LCORL | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2020). OMIA:002246-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2020 | Momozawa, Y., Merveille, A.C., Battaille, G., Wiberg, M., Koch, J., Willesen, J.L., Proschowsky, H.F., Gouni, V., Chetboul, V., Tiret, L., Fredholm, M., Seppälä, E.H., Lohi, H., Georges, M., Lequarré, A.S. : |
Genome wide association study of 40 clinical measurements in eight dog breeds. Sci Rep 10:6520, 2020. Pubmed reference: 32300138. DOI: 10.1038/s41598-020-63457-y. | |
2019 | Plassais, J., Kim, J., Davis, B.W., Karyadi, D.M., Hogan, A.N., Harris, A.C., Decker, B., Parker, H.G., Ostrander, E.A. : |
Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology. Nat Commun 10:1489, 2019. Pubmed reference: 30940804. DOI: 10.1038/s41467-019-09373-w. |
Edit History
- Created by Frank Nicholas on 13 Feb 2020
- Changed by Frank Nicholas on 13 Feb 2020
- Changed by Tosso Leeb on 15 Feb 2020