OMIA 002358-9823 : Resistance/susceptibility to porcine epidemic diarrhea virus (PEDV) in Sus scrofa

Possibly relevant human trait(s) and/or gene(s) (MIM number): 603209 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Tu et al. (2019): "Two single-guide RNAs targeting the CMAH gene and Cas9 mRNA were microinjected into the cytoplasm of newly fertilized eggs. Four live founders generated and proven to be biallelic KO, lacking detectable N-glycolylneuraminic acid (NGNA). The founders were bred, and homozygous offspring were obtained. ... piglets were inoculated with ... PEDV ... results suggest that porcine CMAH KO with nullified NGNA expression are not immune to PEDV but that this KO may lessen the severity of the infection and delay its occurrence." This study used genetically modified animals (GMO).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
CMAH cytidine monophosphate-N-acetylneuraminic acid hydroxylase Sus scrofa 7 NC_010449.5 (19917761..19879367) CMAH Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Zhang, J., Khazalwa, E.M., Abkallo, H.M., Zhou, Y., Nie, X., Ruan, J., Zhao, C., Wang, J., Xu, J., Li, X., Zhao, S., Zuo, E., Steinaa, L., Xie, S. :
The advancements, challenges, and future implications of the CRISPR/Cas9 system in swine research. J Genet Genomics 48:347-360, 2021. Pubmed reference: 34144928. DOI: 10.1016/j.jgg.2021.03.015.
2019 Tu, C.F., Chuang, C.K., Hsiao, K.H., Chen, C.H., Chen, C.M., Peng, S.H., Su, Y.H., Chiou, M.T., Yen, C.H., Hung, S.W., Yang, T.S., Chen, C.M. :
Lessening of porcine epidemic diarrhoea virus susceptibility in piglets after editing of the CMP-N-glycolylneuraminic acid hydroxylase gene with CRISPR/Cas9 to nullify N-glycolylneuraminic acid expression. PLoS One 14:e0217236, 2019. Pubmed reference: 31141512. DOI: 10.1371/journal.pone.0217236.

Edit History


  • Created by Imke Tammen2 on 25 Jun 2021
  • Changed by Imke Tammen2 on 25 Jun 2021