OMIA:002361-9541 : Parkinson disease, PINK1-related in Macaca fascicularis (crab-eating macaque)

In other species: Rhesus monkey , pig

Categories: Nervous system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 608309 (gene) , 605909 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Chen et al. (2021): "injected Cas9-D10A mRNA and two truncated sgRNAs into one-cell-stage cynomolgus zygotes to target the PINK1 gene. We achieved precise and efficient gene editing of the target site in three newborn cynomolgus monkeys. The frame shift mutations of PINK1 in mutant fibroblasts led to a reduction in mRNA. However, western blotting and immunofluorescence staining confirmed the PINK1 protein levels were comparable to that in wild-type fibroblasts." (Genetically modified organism GMO)

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
PINK1 PTEN induced kinase 1 Macaca fascicularis 1 NC_088375.1 (214439640..214421956) PINK1 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002361-9541: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Pan, M.T., Zhang, H., Li, X.J., Guo, X.Y. :
Genetically modified non-human primate models for research on neurodegenerative diseases. Zool Res 45:2095-8137(2024)02-0263-12:263-274, 2024. Pubmed reference: 38287907. DOI: 10.24272/j.issn.2095-8137.2023.197.
2023 Khan, E., Hasan, I., Haque, M.E. :
Parkinson's disease: Exploring different animal model systems. Int J Mol Sci 24:9088, 2023. Pubmed reference: 37240432. DOI: 10.3390/ijms24109088.
Qu, J., Liu, N., Gao, L., Hu, J., Sun, M., Yu, D. :
Development of CRISPR Cas9, spin-off technologies and their application in model construction and potential therapeutic methods of Parkinson's disease. Front Neurosci 17:1223747, 2023. Pubmed reference: 37483347. DOI: 10.3389/fnins.2023.1223747.
2022 Yang, W., Guo, X., Tu, Z., Chen, X., Han, R., Liu, Y., Yan, S., Wang, Q., Wang, Z., Zhao, X., Zhang, Y., Xiong, X., Yang, H., Yin, P., Wan, H., Chen, X., Guo, J., Yan, X.X., Liao, L., Li, S., Li, X.J. :
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis. Protein Cell 13:26-46, 2022. Pubmed reference: 34800266. DOI: 10.1007/s13238-021-00888-x.
2021 Chen, Z.Z., Wang, J.Y., Kang, Y., Yang, Q.Y., Gu, X.Y., Zhi, D.L., Yan, L., Long, C.Z., Shen, B., Niu, Y.Y. :
PINK1 gene mutation by pair truncated sgRNA/Cas9-D10A in cynomolgus monkeys. Zool Res 42:469-477, 2021. Pubmed reference: 34213093. DOI: 10.24272/j.issn.2095-8137.2021.023.
Yang, W., Chen, X., Li, S., Li, X.J. :
Genetically modified large animal models for investigating neurodegenerative diseases. Cell Biosci 11:218, 2021. Pubmed reference: 34933675. DOI: 10.1186/s13578-021-00729-8.

Edit History

  • Created by Imke Tammen2 on 11 Aug 2021
  • Changed by Imke Tammen2 on 11 Aug 2021
  • Changed by Imke Tammen2 on 09 Jan 2022
  • Changed by Imke Tammen2 on 18 Dec 2023