OMIA 002361-9544 : Parkinson disease, PINK1-related in Macaca mulatta

In other species: crab-eating macaque , pig

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 608309 (gene) , 605909 (trait)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
PINK1 PTEN induced putative kinase 1 Macaca mulatta 1 NC_041754.1 (204082118..204064775) PINK1 Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Li, H., Wu, S., Ma, X., Li, X., Cheng, T., Chen, Z., Wu, J., Lv, L., Li, L., Xu, L., Wang, W., Hu, Y., Jiang, H., Yin, Y., Qiu, Z., Hu, X. :
Co-editing PINK1 and DJ-1 genes via adeno-associated virus-delivered CRISPR/Cas9 system in adult monkey brain elicits classical Parkinsonian phenotype. Neurosci Bull 37:1271-1288, 2021. Pubmed reference: 34165772. DOI: 10.1007/s12264-021-00732-6.
Yang, W., Chen, X., Li, S., Li, X.J. :
Genetically modified large animal models for investigating neurodegenerative diseases. Cell Biosci 11:218, 2021. Pubmed reference: 34933675. DOI: 10.1186/s13578-021-00729-8.
Yang, W., Guo, X., Tu, Z., Chen, X., Han, R., Liu, Y., Yan, S., Wang, Q., Wang, Z., Zhao, X., Zhang, Y., Xiong, X., Yang, H., Yin, P., Wan, H., Chen, X., Guo, J., Yan, X.X., Liao, L., Li, S., Li, X.J. :
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis. Protein Cell :, 2021. Pubmed reference: 34800266. DOI: 10.1007/s13238-021-00888-x.
2019 Yang, W., Liu, Y., Tu, Z., Xiao, C., Yan, S., Ma, X., Guo, X., Chen, X., Yin, P., Yang, Z., Yang, S., Jiang, T., Li, S., Qin, C., Li, X.J. :
CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys. Cell Res 29:334-336, 2019. Pubmed reference: 30770867. DOI: 10.1038/s41422-019-0142-y.
Yang, W., Li, S., Li, X.J. :
A CRISPR monkey model unravels a unique function of PINK1 in primate brains. Mol Neurodegener 14:17, 2019. Pubmed reference: 31046796. DOI: 10.1186/s13024-019-0321-9.

Edit History


  • Created by Imke Tammen2 on 31 Aug 2021
  • Changed by Imke Tammen2 on 09 Jan 2022