OMIA:002361-9544 : Parkinson disease, PINK1-related in Macaca mulatta (Rhesus monkey)

In other species: crab-eating macaque , pig

Categories: Nervous system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 608309 (gene) , 605909 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
PINK1 PTEN induced putative kinase 1 Macaca mulatta 1 NC_041754.1 (204082118..204064775) PINK1 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:002361-9544: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Pan, M.T., Zhang, H., Li, X.J., Guo, X.Y. :
Genetically modified non-human primate models for research on neurodegenerative diseases. Zool Res 45:2095-8137(2024)02-0263-12:263-274, 2024. Pubmed reference: 38287907. DOI: 10.24272/j.issn.2095-8137.2023.197.
2023 Dovonou, A., Bolduc, C., Soto Linan, V., Gora, C., Peralta Iii, M.R., Lévesque, M. :
Animal models of Parkinson's disease: bridging the gap between disease hallmarks and research questions. Transl Neurodegener 12:36, 2023. Pubmed reference: 37468944. DOI: 10.1186/s40035-023-00368-8.
Khan, E., Hasan, I., Haque, M.E. :
Parkinson's disease: Exploring different animal model systems. Int J Mol Sci 24:9088, 2023. Pubmed reference: 37240432. DOI: 10.3390/ijms24109088.
Qu, J., Liu, N., Gao, L., Hu, J., Sun, M., Yu, D. :
Development of CRISPR Cas9, spin-off technologies and their application in model construction and potential therapeutic methods of Parkinson's disease. Front Neurosci 17:1223747, 2023. Pubmed reference: 37483347. DOI: 10.3389/fnins.2023.1223747.
2022 Yang, W., Guo, X., Tu, Z., Chen, X., Han, R., Liu, Y., Yan, S., Wang, Q., Wang, Z., Zhao, X., Zhang, Y., Xiong, X., Yang, H., Yin, P., Wan, H., Chen, X., Guo, J., Yan, X.X., Liao, L., Li, S., Li, X.J. :
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis. Protein Cell 13:26-46, 2022. Pubmed reference: 34800266. DOI: 10.1007/s13238-021-00888-x.
2021 Li, H., Wu, S., Ma, X., Li, X., Cheng, T., Chen, Z., Wu, J., Lv, L., Li, L., Xu, L., Wang, W., Hu, Y., Jiang, H., Yin, Y., Qiu, Z., Hu, X. :
Co-editing PINK1 and DJ-1 genes via adeno-associated virus-delivered CRISPR/Cas9 system in adult monkey brain elicits classical Parkinsonian phenotype. Neurosci Bull 37:1271-1288, 2021. Pubmed reference: 34165772. DOI: 10.1007/s12264-021-00732-6.
Yang, W., Chen, X., Li, S., Li, X.J. :
Genetically modified large animal models for investigating neurodegenerative diseases. Cell Biosci 11:218, 2021. Pubmed reference: 34933675. DOI: 10.1186/s13578-021-00729-8.
2019 Yang, W., Liu, Y., Tu, Z., Xiao, C., Yan, S., Ma, X., Guo, X., Chen, X., Yin, P., Yang, Z., Yang, S., Jiang, T., Li, S., Qin, C., Li, X.J. :
CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys. Cell Res 29:334-336, 2019. Pubmed reference: 30770867. DOI: 10.1038/s41422-019-0142-y.
Yang, W., Li, S., Li, X.J. :
A CRISPR monkey model unravels a unique function of PINK1 in primate brains. Mol Neurodegener 14:17, 2019. Pubmed reference: 31046796. DOI: 10.1186/s13024-019-0321-9.

Edit History

  • Created by Imke Tammen2 on 31 Aug 2021
  • Changed by Imke Tammen2 on 09 Jan 2022